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dc.contributor.authorFINALLI, S. L.eng
dc.contributor.authorSILVA, B. P. M. DAeng
dc.contributor.authorGOMES, J. D.eng
dc.contributor.authorALMEIDA, V. V. DEeng
dc.contributor.authorFREITAS, F. A. O.eng
dc.contributor.authorMOREIRA, G. C. M.eng
dc.contributor.authorVIGNATO, B. S.eng
dc.contributor.authorAFONSO, J.eng
dc.contributor.authorREECY, J.eng
dc.contributor.authorKOLTES, J.eng
dc.contributor.authorKOLTES, D.eng
dc.contributor.authorREGITANO, L. C. de A.eng
dc.contributor.authorGARRICK, D. J.eng
dc.contributor.authorBALIEIRO, J. C. DE C.eng
dc.contributor.authorMEIRA, A. N.eng
dc.contributor.authorFREITAS, L.eng
dc.contributor.authorCOUTINHO, L. L.eng
dc.contributor.authorFUKUMASU, H.eng
dc.contributor.authorMOURÃO, G. B.eng
dc.contributor.authorALENCAR, S. M. DEeng
dc.contributor.authorLUCHIARI FILHO, A.eng
dc.contributor.authorCESAR, A. S. M.eng
dc.date.accessioned2022-09-01T17:22:23Z-
dc.date.available2022-09-01T17:22:23Z-
dc.date.created2022-09-01
dc.date.issued2022
dc.identifier.citationAnimals, v. 12, n. 13 1632, jun. 2022.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1145998-
dc.descriptionThe aim of this study was to identify the differentially expressed genes (DEG) from the skeletal muscle and liver samples of animal models for metabolic diseases in humans. To perform the study, the fatty acid (FA) profile and RNA sequencing (RNA-Seq) data of 35 samples of liver tissue (SOY1.5, n = 17 and SOY3.0, n = 18) and 36 samples of skeletal muscle (SOY1.5, n = 18 and SOY3.0, n = 18) of Large White pigs were analyzed. The FA profile of the tissues was modified by the diet, mainly those related to monounsaturated (MUFA) and polyunsaturated (PUFA) FA. The skeletal muscle transcriptome analysis revealed 45 DEG (FDR 10%), and the functional enrichment analysis identified network maps related to inflammation, immune processes, and pathways associated with oxidative stress, type 2 diabetes, and metabolic dysfunction. For the liver tissue, the transcriptome profile analysis revealed 281 DEG, which participate in network maps related to neurodegenerative diseases. With this nutrigenomics study, we verified that different levels of soybean oil in the pig diet, an animal model for metabolic diseases in humans, affected the transcriptome profile of skeletal muscle and liver tissue. These findings may help to better understand the biological mechanisms that can be modulated by the diet.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectFatty acid
dc.subjectRNAseq
dc.subjectHepatic tissue
dc.subjectAnimal model
dc.subjectLongissimus lomborum
dc.titleDifferential gene expression associated with soybean oil level in the diet of pigs.
dc.typeArtigo de periódico
dc.subject.nalthesaurusTranscriptome
dc.subject.nalthesaurusImmune response
dc.subject.nalthesaurusMetabolism
dc.format.extent221 p.
riaa.ainfo.id1145998
riaa.ainfo.lastupdate2022-09-01
dc.identifier.doihttps://doi.org/10.3390/ani12131632
dc.contributor.institutionSIMARA LARISSA FANALLI, University of São Pauloeng
dc.contributor.institutionBRUNA PEREIRA MARTINS DA SILVA, University of São Pauloeng
dc.contributor.institutionJULIA DEZEN GOMES, University of São Pauloeng
dc.contributor.institutionVIVIAN VEZZONI DE ALMEIDA, Federal University of Goiáseng
dc.contributor.institutionFELIPE ANDRÉ OLIVEIRA FREITAS, University of São Pauloeng
dc.contributor.institutionGABRIEL COSTA MONTEIRO MOREIRA, University of Liègeeng
dc.contributor.institutionBÁRBARA SILVA-VIGNATO, University of São Pauloeng
dc.contributor.institutionJULIANA AFONSO, University Federal of São Carloseng
dc.contributor.institutionJAMES REECY, Iowa State Universityeng
dc.contributor.institutionJAMES KOLTES, Iowa State Universityeng
dc.contributor.institutionDAWN KOLTES, Iowa State Universityeng
dc.contributor.institutionLUCIANA CORREIA DE ALMEIDA REGITANO, CPPSEeng
dc.contributor.institutionDORIAN JOHN GARRICK, Massey Universityeng
dc.contributor.institutionJÚLIO CESAR DE CARVALHO BALIEIRO, University of São Pauloeng
dc.contributor.institutionARIANA NASCIMENTO MEIRA, University of São Pauloeng
dc.contributor.institutionLUCIANA FREITAS, DB Genética de Suínoseng
dc.contributor.institutionLUIZ LEHMANN COUTINHO, University of São Pauloeng
dc.contributor.institutionHEIDGE FUKUMASU, University of São Pauloeng
dc.contributor.institutionGERSON BARRETO MOURÃO, University of São Pauloeng
dc.contributor.institutionSEVERINO MATIAS DE ALENCAR, University of São Pauloeng
dc.contributor.institutionALBINO LUCHIARI FILHO, University of São Pauloeng
dc.contributor.institutionALINE SILVA MELLO CESAR, University of São Paulo.eng
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