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dc.contributor.authorSANNOMIYA, M.
dc.contributor.authorRODRIGUES, C. M.
dc.contributor.authorOLIVEIRA, G. C. A.
dc.contributor.authorCARVALHO, J. C. S.
dc.contributor.authorCOSTA, L. S. DA
dc.contributor.authorSPADARI, C. DE C.
dc.contributor.authorFERREIRA, M. J. P.
dc.contributor.authorVILEGAS, W.
dc.contributor.authorISHIDA, K.
dc.date.accessioned2022-09-06T18:06:28Z-
dc.date.available2022-09-06T18:06:28Z-
dc.date.created2022-09-06
dc.date.issued2022
dc.identifier.citationJournal of Ethnopharmacology, n. 297, e115534, 2022.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1146197-
dc.descriptionEthnopharmacological relevance: Byrsonima fagifolia Niedenzu (Malpighiaceae) and other Byrsonima species are popularly employed in Brazilian traditional medicine in the form of preparations as cicatrizing, antiinflammatory, and antimicrobial. Aim of the study: To characterize the phytochemical profile of the hydromethanolic extract obtained from B. fagifolia leaves (BF extract) and to evaluate the toxicity and the antifungal activity. based on extensive analyses of 1D and 2D NMR spectra (HMQC, HMBC and COSY) data. The antifungal effect was determined by the broth microdilution method and the toxicity was evaluated on erythrocytes from sheep?s blood and Galleria mellonella larvae. Results: Phytochemical investigation of the BF extract led to the isolation and characterization of pyrogallol, nbutyl gallate, 3,4-di-O-galloylquinic acid, 3,5-di-O-galloylquinic acid, 3,4,5-tri-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid. The BF extract showed high content of galloylquinic acid derivatives reaching more than twenty-times the quercetin derivatives content, according to the quantification by HPLC. These galloylquinic acid derivatives, obtained during this study, and quercetin derivatives, previously isolated, were submitted to the antifungal assays. The BF extract inhibited yeast growth mainly against Cryptococcus spp., at concentrations of 1?16 ?g/mL, comparable to isolated compounds galloylquinic acid derivatives. However, the quercetin derivatives as well as quinic acid, gallic acid, and methyl gallate showed lower antifungal effect compared with galloylquinic derivatives. In addition, the BF extract had no hemolytic effect and no toxicity on G. mellonella.
dc.language.isoeng
dc.rightsopenAccess
dc.titleGalloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity.
dc.typeArtigo de periódico
dc.subject.thesagroFitotoxicidadeeng
dc.subject.thesagroPlanta Medicinaleng
dc.subject.nalthesaurusMuricidae
dc.subject.nalthesaurusMalpighiaceae
dc.subject.nalthesaurusAntifungal agents
dc.subject.nalthesaurusChemical constituents of plantseng
dc.format.extent25 p.eng
riaa.ainfo.id1146197
riaa.ainfo.lastupdate2022-09-06
dc.identifier.doihttps://doi.org/10.1016/j.jep.2022.115534
dc.contributor.institutionMIRIAM SANNOMIYA, UNIVERSITY OF SÃO PAULO; CLENILSON MARTINS RODRIGUES, CNPAE; GIOVANNA CASTRO ARAÚJO OLIVEIRA, UNIVERSITY OF SÃO PAULO; JULIANA CAJADO SOUZA CARVALHO, UNIVERSITY OF SÃO PAULO; LETÍCIA SERAFIM DA COSTA, UNIVERSITY OF SÃO PAULO; CRISTINA DE CASTRO SPADARI, UNIVERSITY OF SÃO PAULO; MARCELO JOSÉ PENA FERREIRA, UNIVERSITY OF SÃO PAULO; WAGNER VILEGAS, SÃO PAULO STATE UNIVERSITY; KELLY ISHIDA, UNIVERSITY OF SÃO PAULO.
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