Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1150182
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dc.contributor.authorSENA FILHO, J. G. de
dc.contributor.authorALMEIDA, A. S. de
dc.contributor.authorPINTO ZEVALLOS, D.
dc.contributor.authorBARRETO, I. C.
dc.contributor.authorCAVALCANTI, S. C. de H.
dc.contributor.authorNUNES, R.
dc.contributor.authorTEODORO, A. V.
dc.contributor.authorXAVIER, H. S.
dc.contributor.authorBARBOSA FILHO, J. M.
dc.contributor.authorGUAN, L.
dc.contributor.authorNEVES, A. L. A.
dc.contributor.authorDURINGER, J. M.
dc.date.accessioned2022-12-21T16:01:27Z-
dc.date.available2022-12-21T16:01:27Z-
dc.date.created2022-12-21
dc.date.issued2023
dc.identifier.citationCrop Protection, v. 164, 106126, 2023.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1150182-
dc.descriptionMonoterpenes are a highly diverse group of chemical scents that originate from plant secondary metabolic processes, one purpose of which is to serve as a defense against herbivores. Plant-derived monoterpenes pro- duced from Lamiaceae species have demonstrated acaricidal activity against pest mites and ticks. However, the mechanism by which these compounds carry out the demise of this group of arachnids is poorly understood. Here, we review the chemistry and bioactivity of these promising compounds and subsequently assess their potential toxicity to mites and ticks through measurement of their docking ability to amino acid residues of the binding pocket of Drosophila melanogaster acetylcholinesterase (AChE). We identified 27 monoterpenes of the Lamiaceae family from the literature that were effective against mite (Varroidae, Tetranychidae, Eriophyidae) and tick (Ixodidae) species that are problematic in agricultural production. Screening of these compounds showed that monoterpenoids possessing methyl groups, such as carvacrol, linalool, ?-terpineol, bornyl acetate, and terpine-4-ol, strongly bind to D. melanogaster AChE. Linalool, which fits into the binding pocket in the amino acid catalytic triad of AChE (oxyanion hole residues, hydrogen bond interaction with GLU 237, and anionic binding with TRP 83), was identified as the most promising target for further optimization studies. We propose that monoterpenes which interact strongly with amino acid residues of the AChE receptor be targeted for development of effective, naturally produced biocontrol pesticides, as this model demonstrates potential for discovery of new acaricide compounds in a high throughput manner
dc.language.isoeng
dc.rightsopenAccess
dc.subjectBiopesticida
dc.subjectÁcaros
dc.titleFrom plant scent defense to biopesticide discovery: evaluation of toxicity and acetylcholinesterase docking properties for Lamiaceae monoterpenes.
dc.typeArtigo de periódico
dc.subject.thesagroÓleo Essencial
dc.subject.thesagroPesticida
dc.subject.thesagroAroma
dc.subject.nalthesaurusEssential oils
riaa.ainfo.id1150182
riaa.ainfo.lastupdate2022-12-21
dc.contributor.institutionJOSE GUEDES DE SENA FILHO, CPATC; ANDERSON SOARES DE ALMEIDA, UFS; DELIA PINTO ZEVALLOS; IGHOR COSTA BARRETO; SOCRATES CABRAL DE HOLANDA CAVALCANTI; ROGERIA NUNES; ADENIR VIEIRA TEODORO, CPATC; HAROUDO SATIRO XAVIER; JOSE MARIA BARBOSA FILHO; LELUO GUAN; ANDRE L. A. NEVES; JENNIFER M. DURINGER.
Aparece nas coleções:Artigo em periódico indexado (CPATC)

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