Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1150380
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dc.contributor.authorÇIÇEK, S. S.eng
dc.contributor.authorBARBOSA, A. L. P.eng
dc.contributor.authorWENZEL-STORJOHANN, A.eng
dc.contributor.authorSEGOVIA, J. F. O.eng
dc.contributor.authorBEZERRA, R. M.eng
dc.contributor.authorSÖNNICHSEN, F.eng
dc.contributor.authorZIDORN, C.eng
dc.contributor.authorKANZAKI, I.eng
dc.contributor.authorTASDEMIR, D.eng
dc.date.accessioned2022-12-27T18:01:19Z-
dc.date.available2022-12-27T18:01:19Z-
dc.date.created2022-12-27
dc.date.issued2023
dc.identifier.citationPlants, v. 12, n. 1, 99, 2023.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1150380-
dc.descriptionVouacapoua americana (Fabaceae) is an economically important tree in the Amazon region and used for its highly resistant heartwood as well as for medicinal purposes. Despite its frequent use, phytochemical investigations have been limited and rather focused on ecological properties than on its pharmacological potential. In this study, we investigated the phytochemistry and bioactivity of V. americana stem bark extract and its constituents to identify eventual lead structures forfurther drug development. Applying hydrodistillation and subsequent GC-MS analysis, we investigated the composition of the essential oil and identified the 15 most abundant components. Moreover, the diterpenoids deacetylchagresnone (1), cassa-13(14),15-dien-oic acid (2), isoneocaesalpin H (3), (+)-vouacapenic acid (4), and (+)-methyl vouacapenate (5) were isolated from the stem bark, with compounds 2 and 4 showing pronounced effects on Methicillin-resistant Staphylococcus aureus and Enterococcus faecium, respectively. During the structure elucidation of deacetylchagresnone (1), which was isolated from a natural source for the first time, we detected inconsistencies regarding the configuration of the cyclopropane ring. Thus, the structure was revised for both deacetylchagresnone (1) and the previously isolated chagresnone. Following our works on Copaifera reticulata and Vatairea guianensis, the results of this study further contribute to the knowledge of Amazonian medicinal plants.
dc.language.isoeng
dc.rightsopenAccess
dc.titleChemical and biological evaluation of Amazonian medicinal plant Vouacapoua americana Aubl.
dc.typeArtigo de periódico
dc.subject.thesagroAcapu
dc.subject.nalthesaurusCaesalpinioideae
dc.subject.nalthesaurusCytotoxicity
dc.subject.nalthesaurusAntibacterial plants
riaa.ainfo.id1150380
riaa.ainfo.lastupdate2022-12-27
dc.identifier.doihttps://doi.org/10.3390/plants12010099
dc.contributor.institutionSERHAT SEZAI ÇIÇEK, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIELeng
dc.contributor.institutionANNA LAÍS PFEIFER BARBOSA, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIELeng
dc.contributor.institutionARLETTE WENZEL-STORJOHANN, GEOMAR HELMHOLTZ-ZENTRUM FÜR OZEANFORSCHUNG KIELeng
dc.contributor.institutionJORGE FEDERICO ORELLANA SEGOVIA, CPAF-APeng
dc.contributor.institutionROBERTO MESSIAS BEZERRA, UNIVERSIDADE FEDERAL DO AMAPÁeng
dc.contributor.institutionFRANK SÖNNICHSEN, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIELeng
dc.contributor.institutionCHRISTIAN ZIDORN, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIELeng
dc.contributor.institutionISAMU KANZAKI, UNIVERSIDADE DE BRASÍLIAeng
dc.contributor.institutionDENIZ TASDEMIR, GEOMAR HELMHOLTZ-ZENTRUM FÜR OZEANFORSCHUNG KIEL.eng
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