Título:	Molecular mechanisms involved with influenza A nanovaccine immunogenicity in pigs.
Autoria:	IBELLI, A. M. G. PEIXOTO, J. de O. FERNANDES, L. T. HAACH, V. GAVA, D. BASTOS, A. P. A. FONSECA, F. M. da MORES, M. A. Z. CANTAO, M. E. SCHAEFER, R. LEDUR, M. C.
Afiliação:	ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; LANA TEIXEIRA FERNANDES; VANESSA HAACH; DANIELLE GAVA, CNPSA; ANA PAULA ALMEIDA BASTOS, CNPSA; FRANCISCO NOE DA FONSECA, GEM; MARCOS ANTONIO ZANELLA MORES, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; REJANE SCHAEFER, CNPSA; MONICA CORREA LEDUR, CNPSA.
Ano de publicação:	2022
Referência:	In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 12., 2022, Rotterdam. Proceedings: technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers, 2022. Edited by R. F. Veerkamp and Y. de Haas.
Conteúdo:	Abstract: Influenza A virus (IAV) is one of the most important primary agents in porcine respiratory disease complex (PRDC). The gene expression profile was evaluated by RNA-Seq analysis in mediastinal lymph nodes from non-vaccinated and vaccinated pigs with a nanovaccine for IAV to clarify molecular mechanisms and genes involved in the protective immunity conferred by influenza vaccination. A total of 14,381 genes were expressed in the analysed tissue. From those, 564 were differentially expressed (DE) between the two groups. Eighteen biological processes (BP) were enriched in immune response, cell cycle regulation and reproductive processes. The defence response was the BP with more gene counts, including chemokines (CXCL9, CXCL10, CCL8, CXCL8), interleukin (IL21, IL26), interferons (ISG20, IFN-alpha-8), within others. The transcriptome analyses provided a better understanding of the immunogenicity in pigs induced by nanovaccination and could support the development and evaluation of better vaccines for swine and other animal species
Thesagro:	Suíno Doença Respiratória Imunologia Vacina
Palavras-chave:	Imunogenicidade Nanovacinação
Tipo do material:	Artigo em anais e proceedings
Acesso:	openAccess
Aparece nas coleções:	Artigo em anais de congresso (CNPSA)