Título:	Pathogenicity of GI-23 avian infectious bronchitis virus strain isolated in Brazil.
Autoria:	TREVISOL, I. M. CARON, L. MORES, M. A. Z. RECH, D. V. ZANI, G. da S BACK, A. MARCHESI, J. A. P. ESTEVES, P. A.
Afiliação:	IARA MARIA TREVISOL, CNPSA; LUIZINHO CARON, CNPSA; MARCOS ANTONIO ZANELLA MORES, CNPSA; DAIANE VOSS RECH, CNPSA; GABRIEL DA SILVA ZANI, Universidade Federal de Pelotas; ALBERTO BACK, MercoLab Laboratórios; JORGE AUGUSTO PETROLI MARCHESI, MercoLab Laboratórios; PAULO AUGUSTO ESTEVES, CNPSA.
Ano de publicação:	2023
Referência:	Viruses, v. 15, n. 5, p. 1200, 2023.
Conteúdo:	Abstract: IBV variants belonging to the GI-23 lineage have circulated since 1998 in the Middle East and have spread to several countries over time. In Brazil, the first report of GI-23 occurred in 2022. The study aimed to evaluate the in vivo pathogenicity of exotic variant GI-23 isolates. Biological samples were screening by real-time RT-PCR and classified in to GI-1 or G1-11 lineages. Interestingly, 47.77% were not classified in these lineages. Nine of the unclassified strains were sequenced and showed a high similarity to the GI-23 strain. All nine were isolated and three, were studied for pathogenicity. At necropsy, the main observations were the presence of mucus in the trachea and congestion in the tracheal mucosa. In addition, lesions on the tracheas showed marked ciliostasis, and the ciliary activity confirmed the high pathogenicity of isolates. This variant is highly pathogenic to the upper respiratory tract and can cause severe kidney lesions. This study confirm a circulation of GI-23 strain in the country and report, to first time, the isolation of an exotic variant of IBV in Brazil.
Thesagro:	Frango Doença Animal
Palavras-chave:	IBV variant Brazil GI-23 isolate S1 complete sequence Variante do IBV Vírus da Bronquite Infecciosa Aviária GI-23 Patogenicidade da Cepa Chicken disease
Digital Object Identifier:	https://doi.org/10.3390/v15051200
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPSA)