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dc.contributor.authorFELIX, L. A.
dc.contributor.authorGONZAGA, L. W. F.
dc.contributor.authorSOARES, B. C. F.
dc.contributor.authorSUÁREZ, G.
dc.contributor.authorBRANDAO, H. de M.
dc.contributor.authorFACCIOLI-MARTINS, P. Y.
dc.contributor.authorFERRANTE, M.
dc.date.accessioned2023-10-31T13:31:43Z-
dc.date.available2023-10-31T13:31:43Z-
dc.date.created2023-10-31
dc.date.issued2023
dc.identifier.citationArquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 75, n. 6, p. 1087-1096, 2023.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1157597-
dc.descriptionThis study aims to determine therapeutic protocols of intramuscular sodium cloxacillin (IM) in goats with potential antibacterial effects against Staphylococcus spp. We constructed a pharmacokinetic (PK) model of IM, followed by a pharmacokinetic/pharmacodynamic integration (PK/PD). Simulations of different therapeutic protocols were then performed, with the doses ranging from 30 to100 mg/kg every 8, 12, or 24 hours. We calculated the probability to target attainment (PTA) of reach protocol's therapeutic according to the minimum inhibitory concentration (MIC) range of 0.06 to 4 μg/mL. The PK/PD index (PDT) used was "time above the MIC for 40% of the time" (T>MIC ≥40%). Protocols with single administration per day were incapable of achieving PTA ≥ 90% for any of the estimated MICs. However, by decreasing the administration interval, the PTA was increased. Thus, from the dose of 50 mg/kg every 12 hours, a PTA≥ 90% for MICs ≤ 0.5 μg/mL was achieved, while the 30 mg/kg dose every 8 hours was able to achieve a PTA≥ 90% for MICs of 2 μg/mL. The results suggest using 30 mg/kg dose every 8 hours in clinical studies of agents with MICs ≤ 2μg/mL; Nevertheless, the practitioner should adjust the dose in severe patients.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectAntibioticoterapia
dc.subjectSepse
dc.subjectFarmacometria
dc.subjectModelo translacional
dc.subjectSimulação de Monte Carlo
dc.subjectAntibiotic therapy
dc.titlePK/PD integration for intramuscular dose determination of intramuscular sodium cloxacillin for infections caused by Staphylococcus spp in goat.
dc.typeArtigo de periódico
dc.subject.thesagroCaprino
riaa.ainfo.id1157597
riaa.ainfo.lastupdate2023-10-31
dc.contributor.institutionUNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDAD DE LA REPÚBLICA DE MONTEVIDEO; HUMBERTO DE MELLO BRANDAO, CNPGL; PATRICIA YOSHIDA FACCIOLI MARTINS, CNPC; UNIVERSIDADE FEDERAL DE LAVRAS.
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