Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1159154
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dc.contributor.authorSANTOS, A. T. L. dos
dc.contributor.authorCARNEIRO, J. N. P.
dc.contributor.authorCRUZ, R. P. da
dc.contributor.authorSALES, D. L.
dc.contributor.authorPINHEIRO, J. C. A.
dc.contributor.authorFREITAS, M. A. de
dc.contributor.authorKERNTOPF, M. R.
dc.contributor.authorDELMONDES, G. de A.
dc.contributor.authorRIBEIRO, P. R. V.
dc.contributor.authorBRITO, E. S. de
dc.contributor.authorBATISTA, F. L. A.
dc.contributor.authorMAGALHÃES, F. E. A.
dc.contributor.authorPITA NETO, I. C.
dc.contributor.authorBRAGA, M. F. B. M.
dc.contributor.authorKOWALSKI, R.
dc.contributor.authorKOWALSKA, G.
dc.contributor.authorSZOPA, A.
dc.contributor.authorBAJ, T.
dc.contributor.authorCOUTINHO, H. D. M.
dc.date.accessioned2024-01-23T13:42:26Z-
dc.date.available2024-01-23T13:42:26Z-
dc.date.created2023-12-05
dc.date.issued2023
dc.identifier.citationMolecules, Basel, v. 28, n. 1, art. 305, Jan. 2023.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1159154-
dc.descriptionThis study aimed to identify the chemical composition of the Spondias tuberosa aqueous leaf and root extracts (EALST and EARST) and to evaluate their effect, comparatively, against opportunistic pathogenic fungi. Ultra-Performance Liquid Chromatography Coupled to a Quadrupole/Time of Flight System (UPLC-MS-ESI-QTOF) was employed for chemical analysis. Candida albicans and C. tropicalis standard strains and clinical isolates were used (CA INCQS 40006, CT INCQS 40042, CA URM 5974, and CT URM 4262). The 50% Inhibitory Concentration for the fungal population (IC50) was determined for both the intrinsic action of the extracts and the extract/fluconazole (FCZ) associations. The determination of the Minimum Fungicidal Concentration (MFC) and the verification of effects over fungal morphological transitions were performed by subculture in Petri dishes and humid chambers, respectively, both based on micro-dilution. UPLC-MS-ESI-QTOF analysis revealed the presence of phenolic and flavonoid compounds. The association of the extracts with fluconazole, resulted in IC50 values from 2.62 µg/mL to 308.96 µg/mL. The MFC of the extracts was ?16,384 µg/mL for all tested strains, while fluconazole obtained an MFC of 8192 µg/mL against C. albicans strains. A reduction in MFC against CA URM 5974 (EALST: 2048 µg/mL and EARST: 1024 µg/mL) occurred in the extract/fluconazole association.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectPopular medicine
dc.titleUPLC-MS-ESI-QTOF analysis and antifungal activity of aqueous extracts of Spondias tuberosa.
dc.typeArtigo de periódico
dc.subject.thesagroUmbu
dc.subject.thesagroSpondias Tuberosa
dc.subject.thesagroCromatografia
dc.subject.nalthesaurusFlavonoids
dc.subject.nalthesaurusFluconazole
dc.subject.nalthesaurusUltra-performance liquid chromatography
dc.subject.nalthesaurusMass spectrometry
dc.subject.nalthesaurusElectrospray ionization mass spectrometry
dc.format.extent214 p.
riaa.ainfo.id1159154
riaa.ainfo.lastupdate2024-01-23
dc.identifier.doihttps://doi.org/10.3390/molecules28010305
dc.contributor.institutionANTONIA THASSYA LUCAS DOS SANTOS, UNIVERSIDADE REGIONAL DO CARIRI
dc.contributor.institutionJOARA NÁLYDA PEREIRA CARNEIRO, UNIVERSIDADE REGIONAL DO CARIRIeng
dc.contributor.institutionRAFAEL PEREIRA DA CRUZ, UNIVERSIDADE REGIONAL DO CARIRIeng
dc.contributor.institutionDÉBORA LIMA SALES, UNIVERSIDADE REGIONAL DO CARIRIeng
dc.contributor.institutionJACQUELINE COSMO ANDRADE-PINHEIRO, UNIVERSIDADE REGIONAL DO CARIRIeng
dc.contributor.institutionMARIA AUDILENE DE FREITAS, UNIVERSIDADE FEDERAL DE PERNAMBUCOeng
dc.contributor.institutionMARTA REGINA KERNTOPF, UNIVERSIDADE REGIONAL DO CARIRIeng
dc.contributor.institutionGYLLYANDESON DE ARAÚJO DELMONDES, UNIVERSIDADE REGIONAL DO CARIRIeng
dc.contributor.institutionPAULO RICELI VASCONCELOS RIBEIRO, CNPATeng
dc.contributor.institutionEDY SOUSA DE BRITO, CNATeng
dc.contributor.institutionFRANCISCO LUCAS ALVES BATISTA, UNIVERSIDADE REGIONAL DO CARIRIeng
dc.contributor.institutionFRANCISCO ERNANI ALVES MAGALHÃES, UNIVERSIDADE ESTADUAL DO CEARÁeng
dc.contributor.institutionIVO CAVALCANTE PITA NETO, FACULDADE CECAPEeng
dc.contributor.institutionMARIA FLAVIANA BEZERRA MORAIS-BRAGA, UNIVERSIDADE REGIONAL DO CARIRIeng
dc.contributor.institutionRADOSŁAW KOWALSKI, UNIWERSYTET PRZYRODNICZNY W LUBLINIEeng
dc.contributor.institutionGRAZYNA KOWALSKA, UNIWERSYTET PRZYRODNICZNY W LUBLINIEeng
dc.contributor.institutionALEKSANDRA SZOPA, UNIWERSYTET MEDYCZNY W LUBLINIEeng
dc.contributor.institutionTOMASZ BAJ, UNIWERSYTET MEDYCZNY W LUBLINIEeng
dc.contributor.institutionHENRIQUE DOUGLAS MELO COUTINHO, UNIVERSIDADE REGIONAL DO CARIRI.eng
Appears in Collections:Artigo em periódico indexado (CNPAT)

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