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dc.contributor.authorSCHAEFER, R.
dc.contributor.authorGAVA, D.
dc.contributor.authorBOMBASSARO, G. E.
dc.contributor.authorHAACH, V.
dc.contributor.authorMACIAG, S. S.
dc.contributor.authorBASTOS, A. P. A.
dc.date.accessioned2024-09-24T20:53:49Z-
dc.date.available2024-09-24T20:53:49Z-
dc.date.created2024-09-24
dc.date.issued2024
dc.identifier.citationVirology, v. 600, n. 110248, 2024.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1167567-
dc.descriptionAbstract: Senecavirus A (SVA) is a Picornaviridae RNA virus that causes vesicular disease (VD) and transitory neonatal losses in pigs. The major ways SVA is spread are by oral, nasal, and feces. Vertical transmission of SVA was investigated during a VD epidemic in a farrow-to-finish herd in Brazil. Vesicular lesions were observed on sows before farrowing and on piglets within 24 h of birth. Analyses included RT-qPCR, viral isolation, sequencing, and virus-neutralization assays on serum, vesicular fluid, colostrum, and milk. Five out of ten sows were viremic before farrowing, and 46.7% of tested piglets had high viral loads in the first 24 h after birth. Infectious virus was detected in colostrum and milk from one postnatal sow. Despite high levels of neutralizing antibodies (nAbs) in piglet serum, colostrum, and milk, piglets were not protected from viremia and clinical illness. These findings support the vertical and congenital transmission of SVA.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectVirolactia
dc.subjectSenecavirus A
dc.subjectVertical transmission
dc.titleEvidence of vertical transmission of Senecavirus A in naturally infected sows.
dc.typeArtigo de periódico
dc.subject.thesagroLeitão
dc.subject.thesagroColostro
dc.subject.thesagroVirologia
dc.subject.thesagroTransmissão de Doença
dc.subject.nalthesaurusColostrum
dc.subject.nalthesaurusPiglets
riaa.ainfo.id1167567
riaa.ainfo.lastupdate2024-09-24
dc.identifier.doihttps://doi.org/10.1016/j.virol.2024.110248
dc.contributor.institutionREJANE SCHAEFER, CNPSA; DANIELLE GAVA, B UNIVERSIDADE FEDERAL DO RIO GRANDE DO SU; GABRIELLY E. BOMBASSARO, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; VANESSA HAACH, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; SHAIANA SALETE MACIAG, UNIVERSIDADE ESTADUAL DO CENTRO-OESTE DO PARANA; ANA PAULA ALMEIDA BASTOS, CNPSA.
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