Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1169333
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dc.contributor.authorARAUJO, T. F.
dc.contributor.authorSILVA, L. P. da
dc.date.accessioned2024-11-21T19:06:32Z-
dc.date.available2024-11-21T19:06:32Z-
dc.date.created2024-11-21
dc.date.issued2024
dc.identifier.citationCoatings, v. 14, n. 10, 1324, 2024.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1169333-
dc.descriptionCentral composite design (CCD) is a statistical experimental design technique that utilizes a combination of factorial and axial points to study the effects of multiple variables on a response. This study focused on optimizing hydrogel formulations for 3D printing using CCD. Three biopolymers were selected: sodium alginate (SA), gelatin (GEL), and carboxymethyl cellulose (CMC). The maximum and minimum concentrations of each polymer were established using a Google Scholar search, and CCD was employed to generate various combinations for hydrogel preparation. The hydrogels were characterized in accordance with their swelling degree (SD) in phosphate-buffered saline (PBS) and Dulbecco’s Modified Eagle Medium (DMEM), as well as their printability in 2D and 3D assays. The formulation consisting of 7.5% SA, 7.5% GEL, and 2.5% CMC exhibited the best swelling properties and exceptional printability, surpassing all other tested formulations. This study highlights the effectiveness of design of experiment methodologies in accelerating the development of optimized hydrogel formulations for various applications in 3D printing and suggests avenues for future research to explore their performance in specific biological contexts.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectPolymer
dc.subjectSwelling
dc.subject3D bioprinting
dc.subjectDesign of experiments
dc.subjectPrintability
dc.titleThe Utilization of Central Composite Design for the Production of Hydrogel Blends for 3D Printing.
dc.typeArtigo de periódico
dc.description.notesNa publicação: Luciano Paulino Silva.
riaa.ainfo.id1169333
riaa.ainfo.lastupdate2024-11-21
dc.identifier.doihttps://doi.org/10.3390/coatings14101324
dc.contributor.institutionTHALITA FONSECA ARAUJO, UNIVERSITY OF BRASÍLIA; LUCIANO PAULINO DA SILVA, CENARGEN.
Aparece nas coleções:Artigo em periódico indexado (CENARGEN)

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