Title:	Study of the chemical diversity in Spondias tuberosa leaves during the phenological evolution stages: metabolomic and chemometric approaches associated with antioxidant and antiglycant activities.
Authors:	NASCIMENTO, F. W. M. do GONDIM, T. A. RIBEIRO, P. R. V. LIMA, M. A. C. de OLIVEIRA, V. R. de CÂMARA NETO, J. F. RIBEIRO, M. E. N. P. FERRARI, A. B. S. ZERAIK, M. L. GUEDES, J. A. C. ZOCOLO, G. J.
Affiliation:	FRANCISCO WENDELL M. DO NASCIMENTO, UNIVERSIDADE FEDERAL DO CEARÁ; TAMYRIS A. GONDIM, UNIVERSIDADE FEDERAL DO CEARÁ; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; MARIA AUXILIADORA COELHO DE LIMA, CPATSA; VISELDO RIBEIRO DE OLIVEIRA, CPATSA; JOÃO FRANCISCO CÂMARA NETO, UNIVERSIDADE FEDERAL DO CEARÁ; MARIA ELENIR N. P. RIBEIRO, UNIVERSIDADE FEDERAL DO CEARÁ; ANNA BEATRIZ S. FERRARI, UNIVERSIDADE ESTADUAL DE LONDRINA; MARIA LUIZA ZERAIK, UNIVERSIDADE ESTADUAL DE LONDRINA; JHONYSON A. C. GUEDES, UNIVERSIDADE FEDERAL DO CEARÁ; GUILHERME JULIAO ZOCOLO, CNPSO.
Date Issued:	2025
Citation:	Journal of the Brazilian Chemical Society, v. 36, n. 5, e-20240219, 2025.
Description:	Spondias tuberosa (umbu) has been studied from the perspective of natural product and pharmacology, revealing relevant biological activities. Therefore, from the point of view of chemical and biological studies, deepening knowledge about this species is of great importance. Additionally, the evaluation related to the metabolic variations of the same species during different phenological evolution stages is also an interesting aspect of the research. Thereby, ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-QToF-MSE) was used to trace the chemical profile from umbu leaves at different phenological stages, allowing the detection of 40 metabolites, which 16 were annotated, such as phenolics and anacardic acids. Furthermore, the use of chemoinformatics tools allowed obtaining information on phenological development in the three leaves phases: post-flowering (young leaves), full production and senescence. The antiglycation activity assay revealed a potential inhibition of the formation of advanced glycation end-products (AGEs) in the leaves at different phenological stages. The antioxidant activity was satisfactory and in agreement with previously reported results, evidencing the potential for using umbu leaves, currently completely discarded, as an alternative source of antioxidants, which may provide increased added value to the cultivation of umbu, stimulating family farming and the recovery of tree density in degraded areas. Keywords: umbu, liquid chromatography, multivariate analysis, mass spectrometry, metabolic variation
Thesagro:	Umbu Caatinga Spondias Tuberosa Fenologia Espécie Nativa
NAL Thesaurus:	Spondias Liquid chromatography Multivariate analysis Mass spectrometry
Keywords:	Cromatografia líquida Análise multivariada Espectrometria de massas Variação metabólica Bioma caatinga
DOI:	https://dx.doi.org/10.21577/0103-5053.20240219
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPATSA)