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dc.contributor.authorBONATTO, C. C.
dc.contributor.authorREIS, I. G.
dc.contributor.authorRIBEIRO, D. J. S.
dc.contributor.authorALMEIDA, R. das N.
dc.contributor.authorCORRÊA, R.
dc.contributor.authorDOURADO, L. P. S.
dc.contributor.authorPASQUARELLI-DO-NASCIMENTO, G.
dc.contributor.authorMAGALHÃES, K. G.
dc.contributor.authorSILVA, L. P. da
dc.date.accessioned2025-10-23T12:48:38Z-
dc.date.available2025-10-23T12:48:38Z-
dc.date.created2025-10-23
dc.date.issued2025
dc.identifier.citationPharmaceuticals, v. 18, n. 7, 993, 2025.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1180502-
dc.descriptionIn recent years, silver nanoparticles (AgNPs) have garnered significant attention due to their potent antimicrobial properties, which hold promise for various applications. However, concerns about their potential toxicity have also emerged, particularly regarding their impact on human and animal health. This study investigates the acute toxicological effects of AgNPs synthesized using a green route with an aqueous extract of a native Cerrado plant (AgNPs-Cb) in mice. Methods: The AgNPs-Cb were intravenously administered at a concentration of 64 µM, and the mice were euthanized after 24 h for the collection of blood and organ samples (liver, spleen, kidneys, and lungs) for hematological, biochemical, and histological analyses. Results: Hematological analysis, including complete blood count (CBC) and differential leukocyte count, showed no statistically significant alterations in the groups treated with AgNPs-Cb, Cb extract, and Ag+, compared with the control group (p < 0.05). Notably, only the Ag+ group exhibited a significant increase in red blood cell count and hematocrit levels, suggesting that the nanoformulation of silver might mitigate the hematological impact seen with free silver ions. Biochemical analyses of liver and kidney function markers also revealed no significant differences across the treatment groups. Conclusions: These findings indicate that AgNPs-Cb may offer a safer alternative for antimicrobial applications, reducing the risk of acute toxicity in mammals while maintaining efficacy against pathogens. Further studies are needed to explore the underlying mechanisms and long-term effects of AgNPs-Cb exposure.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectAgNPs
dc.subjectNanosafety
dc.subjectGreen synthesis
dc.subjectHematological analysis
dc.subjectBiochemical analysis
dc.subjectHistological analysis
dc.titleNanotoxicological assessment of green-synthesized silver nanoparticles from Brazilian Cerrado plant in a murine model.
dc.typeArtigo de periódico
dc.subject.thesagroCaryocar Brasiliense
dc.subject.thesagroCerrado
dc.description.notesNa publicação: Luciano Paulino Silva.
riaa.ainfo.id1180502
riaa.ainfo.lastupdate2025-10-23
dc.identifier.doihttps://doi.org/10.3390/ph18070993
dc.contributor.institutionCÍNTHIA CAETANO BONATTO, UNIVERSITY OF BRASILIA (UNB)
dc.contributor.institutionIVY GARCEZ REIS, UNIVERSITY OF BRASILIA (UNB)eng
dc.contributor.institutionDALILA JULIANA SILVA RIBEIRO, UNIVERSITY OF BRASILIA (UNB)eng
dc.contributor.institutionRAQUEL DAS NEVES ALMEIDA, UMASS CHAN MEDICAL SCHOOLeng
dc.contributor.institutionRAFAEL CORRÊA, UNIVERSITY OF BRASILIA (UNB)eng
dc.contributor.institutionLIVIA PIMENTEL SANT’ANA DOURADO, UNIVERSITY OF BRASILIA (UNB)eng
dc.contributor.institutionGABRIEL PASQUARELLI-DO-NASCIMENTO, UNIVERSITY OF BRASILIA (UNB)eng
dc.contributor.institutionKELLY GRACE MAGALHÃES, UNIVERSITY OF BRASILIA (UNB)eng
dc.contributor.institutionLUCIANO PAULINO DA SILVA, CENARGEN.eng
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