Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1180667
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dc.contributor.authorAHMAD, I.
dc.contributor.authorCARDOSO, J. de S.
dc.contributor.authorMELLO, J. E. de
dc.contributor.authorTEIXEIRA, F. C.
dc.contributor.authorSARAIVA, J. T.
dc.contributor.authorBONA, N. P.
dc.contributor.authorVIZZOTTO, M.
dc.contributor.authorSOUZA, L. P. de
dc.contributor.authorDOMINGUES, W. B.
dc.contributor.authorCAMPOS, V. F.
dc.contributor.authorLENCINA, C. L.
dc.contributor.authorSPANEVELLO, R. M.
dc.contributor.authorTAVARES, E. G.
dc.contributor.authorAGUIAR, M. S. S. de
dc.contributor.authorSTEFANELLO, F. M.
dc.date.accessioned2025-10-28T18:56:16Z-
dc.date.available2025-10-28T18:56:16Z-
dc.date.created2025-10-28
dc.date.issued2025
dc.identifier.citationNeurochemical Research, v. 50, article number 335, 2025.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1180667-
dc.descriptionThe current study aimed to evaluate the in-vitro toxicity and in-vivo antidiabetic effects of a standardized extract from Eugenia uniflora (E. uniflora) fruit, comparing its efficacy to metformin (Met), a widely used anti-hyperglycemic drug. First, toxicity of the extract was determined by MTT assay in 3T3 cell line and primary astrocyte culture. Then Wistar rats were divided into four groups: I- Control, II- type 2 diabetes mellitus (T2DM), III- T2DM + Met and IV- T2DM + E. uniflora. To induce T2DM, groups II, III and IV received a high fat diet (HFD) for 3 weeks followed by a single intraperitoneal (i.p.) dose of streptozotocin (STZ, 35 mg/kg). Animals of group I received normal diet and vehicle (i.p.). Group III received Met (250 mg/kg) and group IV received E. uniflora (200 mg/kg) intragastric pathway, once a day, throughout all experimental protocol. Animals from the groups I and II received water in the same volume. Results showed that cell viability was not affected. In-vivo, E. uniflora and Met prevented the change in serum levels of glucose, cholesterol, LDL, triglyceride and interleukin-6. Furthermore, extract and Met improved oxidative stress markers and antioxidant enzyme activity in the brain (cerebral cortex, hippocampus, striatum). Furthermore, extract enhanced the downstream insulin signaling pathway, including insulin receptor substrate 1, forkhead box protein O-3a, as well as activated the nuclear factor erythroid 2-related factor 2 in the cerebral cortex. This study indicates that E. uniflora extract may have potential in preventing complications associated with T2DM; nevertheless, additional studies are required to confirm these effects and establish their clinical significance.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectInterleucina-6
dc.subjectDiabetes tipo 2
dc.subjectHiperglicemia
dc.subjectType 2 diabetes
dc.titleProtective effects of Eugenia uniflora red fruit on brain in a rat model of type 2 diabetes: mechanistic insights.
dc.typeArtigo de periódico
dc.subject.thesagroMedicamento Homeopático
dc.subject.thesagroEugenia Uniflora
dc.subject.thesagroInsulina
dc.subject.thesagroCérebro
dc.subject.nalthesaurusHyperglycemia
dc.subject.nalthesaurusInsulin
dc.subject.nalthesaurusInterleukin-6
dc.subject.nalthesaurusBrain
riaa.ainfo.id1180667
riaa.ainfo.lastupdate2025-10-28
dc.identifier.doihttps://doi.org/10.1007/s11064-025-04587-5
dc.contributor.institutionIMTIAZ AHMAD, UNIVERSIDADE FEDERAL DE PELOTAS
dc.contributor.institutionJULIANE DE SOUZA CARDOSO, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionJULIA EISENHARDT DE MELLO, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionFERNANDA CARDOSO TEIXEIRA, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionJULIANE TORCHELSEN SARAIVA, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionNATÁLIA PONTES BONA, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionMARCIA VIZZOTTO FOSTER, CPACTeng
dc.contributor.institutionLUCAS PETITEMBERTE DE SOUZA, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionWILLIAM BORGES DOMINGUES, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionVINICIUS FARIAS CAMPOS, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionCLAITON LEONETI LENCINA, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionROSELIA MARIA SPANEVELLO, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionREJANE GIACOMELLI TAVARES, UNIVERSIDADE LUSÓFONA DE HUMANIDADES E TECNOLOGIASeng
dc.contributor.institutionMAYARA SANDRIELLY SOARES DE AGUIAR, UNIVERSIDADE FEDERAL DE PELOTASeng
dc.contributor.institutionFRANCIELI MORO STEFANELLO, UNIVERSIDADE FEDERAL DE PELOTAS.eng
Appears in Collections:Artigo em periódico indexado (CPACT)

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