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dc.contributor.authorARAÚJO JÚNIOR, M. B. de
dc.contributor.authorSANTOS, A. O.
dc.contributor.authorRODRIGUES, A. M.
dc.contributor.authorSOUSA, T. F.
dc.contributor.authorSILVA, F. M. A. da
dc.contributor.authorANGOLINI, C. F. F.
dc.contributor.authorGALAVERNA, R. S.
dc.contributor.authorMEDEIROS, L. S. de
dc.contributor.authorCASARIN, F. E.
dc.contributor.authorYAMAGISHI, M. E. B.
dc.contributor.authorSILVA, G. F. da
dc.contributor.authorKOOLEN, H. H. F.
dc.date.accessioned2025-11-06T10:49:11Z-
dc.date.available2025-11-06T10:49:11Z-
dc.date.created2025-11-03
dc.date.issued2025
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 36, n. 11, e-20250146, 2025.
dc.identifier.issn1678-4790
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1180963-
dc.descriptionOosporein (OOS) is the major specialized metabolite produced by the fungus Arcopilus amazonicus, an endophyte from Paullinia cupana. Genes related to the biosynthesis of this molecule in A. amazonicus diverge from those found in Beauveria bassiana. Furthermore, high-resolution liquid chromatography coupled with mass spectrometry combined with molecular networking, revealed the production of analogous compounds with varying degrees of oxygenation. Based on these analytical data, the analogues were annotated as phoenicin diquinol (2), phoenicin quinol (4) and phoenicin (5). By combining mass spectrometry and genome mining, a comprehensive biosynthetic pathway is proposed for these compounds, including the feasibility of a novel putative biphenol oxidation pathway mediated by the monooxygenase gene AAm15, which is exclusive to A. amazonicus. Additionally, the production of OOS, 2, 4 and 5 by a single fungal species is reported for the first time.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectArcopilus
dc.subjectEspectrometria de massa
dc.subjectOosporina
dc.subjectFenicina
dc.subjectPhoenicin
dc.subjectOosporein
dc.titleProduction of oosporein and related bibenzoquinone analogues in Arcopilus amazonicus revealed by genome mining and Mass Spectrometry Analysis.
dc.typeArtigo de periódico
dc.subject.thesagroBiossíntese
dc.subject.nalthesaurusBiosynthesis
riaa.ainfo.id1180963
riaa.ainfo.lastupdate2025-11-06
dc.identifier.doihttps://dx.doi.org/10.21577/0103-5053.20250146
dc.contributor.institutionMOYSÉS B. DE ARAÚJO JÚNIOR, UNIVERSIDADE FEDERAL DO AMAZONAS; ALINE O. SANTOS, UNIVERSIDADE DO ESTADO DO AMAZONAS; ALINE M. RODRIGUES, UNIVERSIDADE DO ESTADO DO AMAZONAS; THIAGO F. SOUSA; FELIPE M. A. DA SILVA, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; CÉLIO F. F. ANGOLINI, UNIVERSIDADE FEDERAL DO ABC; RENAN S. GALAVERNA, UNIVERSIDADE ESTADUAL DE CAMPINAS; LÍVIA S. DE MEDEIROS, UNIVERSIDADE FEDERAL DE SÃO PAULO; FABIANA E. CASARIN, UNIVERSIDADE FEDERAL DE SÃO PAULO; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA; GILVAN FERREIRA DA SILVA, CPAA; HECTOR H. F. KOOLEN, UNIVERSIDADE DO ESTADO DO AMAZONAS.
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