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dc.contributor.authorCANALLI, G. F. D.
dc.contributor.authorALENCAR, M. F. D. de
dc.contributor.authorBELLO, H. J. S.
dc.contributor.authorOKINO, C. H.
dc.contributor.authorCOSTA, E. C. da
dc.contributor.authorCUNHA, A. F. da
dc.contributor.authorKAPRITCHKOFF, R. T. I.
dc.contributor.authorCORRÊA, L. G. P.
dc.contributor.authorCHAGAS, A. C. de S.
dc.contributor.authorALBUQUERQUE, A. C. A. de
dc.date.accessioned2025-11-25T15:48:58Z-
dc.date.available2025-11-25T15:48:58Z-
dc.date.created2025-11-25
dc.date.issued2025
dc.identifier.citationIn: CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENTS OF VETERINARY PARASITOLOGY, 30., 2025, Curitiba. Abstract book. Curitiba: Universidade Federal do Paraná, 2025. p. 251-252.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1181880-
dc.descriptionAbstract: Sheep exhibit two distinct β-globin haplotypes, Hb-A and Hb-B. During anemic conditions, Hb-A animals can express juvenile βC, which displays a higher affinity for oxygen, an ability absent in Hb-B animals. β-globin haplotypes have been associated with variable sheep resistance/resilience to gastrointestinal nematode infection. This research aimed to compare the adaptive immune response in the abomasum of lambs of different breeds and β-globin haplotypes artificially infected by Haemonchus contortus. Twenty-one male lambs, comprising 12 Santa Inês (SI), 5 Texel (TX), and 4 White Dorper (DO), with six months old, were selected from the Embrapa Southeastern Livestock experimental farm based on their β-globin types (AA, AB, BB) through blood DNA analysis. Subsequently, those lambs were dewormed and received a single dosage of 4,000 H. contortus L3. Twenty-eight days post-infection, they were slaughtered, and the fundic region of abomasum tissue was formalin-fixed and paraffinembedded for immunohistochemistry analysis of MHC II (HLA-DR) and T lymphocytes (CD3) cells. Positive cell counting was performed in ten random fields under a 40x objective with a 1 mm² graticule. There was no effect of haplotype in MHC II+ (p = 0.980) (AA: 248±60.6; AB: 234±47.1 and BB: 254±121.8) and in CD3+ means (p = 0.140) (AA: 1122±304.9; AB: 976±820.3 and BB: 520±595.5). Similar results were observed for breed effect in MHC II+ (p = 0.130) (DO: 162±77.7; SI: 263±83.3 and TX: 280.6±114.5) and CD3+ means (p = 0.787) (DO: 1360±278.9; SI: 1233±778.2 and TX: 1473±497.4). The limited presence of AA animals in the flock may have influenced the absence of differences among haplotypes. This similar immunological response is being better investigated with a larger number of animals, as there seemed to be a tendency for AA animals to have a higher average of CD3+, along with a breed effect in MHC II+ of SI and TX compared to DO.
dc.language.isoeng
dc.rightsopenAccess
dc.titleAssessing the immune response of different ß-globin haplotypes and breed in Haemonchus contortus infected sheep.
dc.typeResumo em anais e proceedings
dc.subject.thesagroOvelha
dc.subject.thesagroHaemonchus Contortus
dc.subject.nalthesaurusHaplotypes
dc.subject.nalthesaurusLambs
dc.subject.nalthesaurusAbomasum
dc.subject.nalthesaurusHaemonchus
dc.subject.nalthesaurusImmune response
riaa.ainfo.id1181880
riaa.ainfo.lastupdate2025-11-25
dc.contributor.institutionGUILHERME FERNANDES DIAS CANALLI, UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO; MARIA FLÁVIA DIAS DE ALENCAR, UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO; HORNBLENDA JOAQUINA SILVA BELLO, FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO; CINTIA HIROMI OKINO, CPPSE; ESTEVÃO CAMILLO DA COSTA, CENTRO UNIVERSITÁRIO CENTRAL PAULISTA; AMANDA FREITAS DA CUNHA, CENTRO UNIVERSITÁRIO CENTRAL PAULISTA; RAFAELA TAMI IKEDA KAPRITCHKOFF, UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO; LORRANE GABRIELE PINHEIRO CORRÊA, UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; ANA CLÁUDIA ALEXANDRE DE ALBUQUERQUE, UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO.
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