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dc.contributor.authorBARRETO, D. L. C.
dc.contributor.authorCANTRELL, C. L.
dc.contributor.authorKIM, S. J.
dc.contributor.authorCARVALHO, C. R. de
dc.contributor.authorQUEIROZ, S. C. do N. de
dc.contributor.authorBAJSA-HIRSCHEL, J.
dc.contributor.authorTAMANG, P.
dc.contributor.authorDUKE, S. O.
dc.contributor.authorROSA, L. H.
dc.date.accessioned2025-11-27T14:48:54Z-
dc.date.available2025-11-27T14:48:54Z-
dc.date.created2025-11-27
dc.date.issued2025
dc.identifier.citationAnais da Academia Brasileira de Ciências, v. 97, n. 3, p.e20241059, 2025.
dc.identifier.issn1678-2690
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1181976-
dc.descriptionAbstract: Our study focused on the phytotoxic and antifungal activities of metabolites isolated from Fusarium sp., an endophyte associated with the medicinal plant Piper sp. Chromatographic separations of the Fusarium sp. crude extract led to the isolation of three analogous compounds: anhydrofusarubin (1), 5,10-dihydroxy-1,7-dimethoxy-3- methyl-1H-benzo[g]isochromene-6,9-dione (2), and javanicin (3). The structures of the isolated compounds were determined by high-resolution mass spectrometry (HRMS) analysis and direct comparison of 13C NMR data with that reported in the literature. The isolated compounds were evaluated for phytotoxic activity against Lactuca sativa and Agrostis stolonifera. All compounds exhibited strong phytotoxic activity on both plant species, completely inhibiting seed germination at a concentration of 1 mg mL1 . Additionally, the isolated compounds were evaluated against Lemna paucicostata, achieving a 50% growth inhibition (IC50) at concentration of 64, 28, and 31 μM for compounds 1, 2, and 3, respectively. The antifungal activity of these compounds was evaluated using a bioautography assay targeting the agricultural pathogen Colletotrichum fragariae. Among them, compound 2 demonstrated significant antifungal activity. Our results showed that tropical medicinal plants harbor an interesting endophyte that has a potential reservoir of bioactive compounds. Moreover, the structures of these compounds could serve as scaffold for the development of new pesticides.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectEndophytic fungus
dc.titlePhytotoxic and antifungal compounds for agriculture are interestingly produced by the endophytic fungus Fusarium sp. (Ascomycota) isolated from Piper sp. (Piperaceae).
dc.typeArtigo de periódico
dc.subject.thesagroPiperaceae
dc.subject.thesagroPimenta
dc.subject.thesagroFungo Para Controle Biológico
dc.subject.thesagroFusarium
dc.subject.thesagroColletotrichum Fragariae
dc.subject.nalthesaurusEndophytes
dc.subject.nalthesaurusBiological control agents
dc.subject.nalthesaurusAntifungal agents
dc.subject.nalthesaurusMetabolites
dc.subject.nalthesaurusPiper
dc.subject.nalthesaurusMicrobial pesticides
riaa.ainfo.id1181976
riaa.ainfo.lastupdate2025-11-27
dc.identifier.doihttps://doi.org/10.1590/0001-3765202520241059
dc.contributor.institutionDEBORA LUIZA C. BARRETO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; CHARLES L. CANTRELL, UNITED STATES DEPARTMENT OF AGRICULTURE; SEONG J. KIM, UNITED STATES DEPARTMENT OF AGRICULTURE; CAMILA R. DE CARVALHO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; SONIA CLAUDIA DO NASCIMENTO DE QUEIROZ, CNPMA; JOANNA BAJSA-HIRSCHEL, UNITED STATES DEPARTMENT OF AGRICULTURE; PRABIN TAMANG, UNITED STATES DEPARTMENT OF AGRICULTURE; STEPHEN OSCAR DUKE, UNIVERSITY OF MISSISSIPPI; LUIZ HENRIQUE ROSA, UNIVERSIDADE FEDERAL DE MINAS GERAIS.
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