Título:	Acute toxicity and hematological effects of a silver nanoparticle–Terminalia catappa nanocomposite in juvenile tambaqui (Colossoma macropomum).
Autoria:	MENESES, J. O. CUNHA, F. dos S. DIAS, J. A. R. SOUSA, N. da C. COUTO, M. V. S. do ABE, H. A. CUNHA, A. F. S. dA CARDOSO, J. C. COSTA, L. P. da ALVES, L. L. PAIXÃO, P. E. G. FUJIMOTO, R. Y.
Afiliação:	JULIANA OLIVEIRA MENESES, UNIVERSIDADE TIRADENTES; FERNANDA DOS SANTOS CUNHA, INSTUTO FEDERAL DE RORAIMA; JOEL ARTUR RODRIGUES DIAS, UNIVERSIDADE FEDERAL DO MARANHÃO; NATALINO DA COSTA SOUSA, INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DO MATO GROSSO DO SUL; MÁRCIA VALÉRIA SILVA DO COUTO, CASA ESCOLA DA PESCA; HIGO ANDRADE ABE, UNIVERSIDADE FEDERAL DA BAHIA; ANA FLÁVIA SANTOS DA CUNHA, UNIVERSIDADE FEDERAL DE SERGIPE; JULIANA CORDEIRO CARDOSO, UNIVERSIDADE TIRADENTES; LUIZ PEREIRA DA COSTA, UNIVERSIDADE FEDERAL DE SERGIPE; LUMAR LUCENA ALVES, CHRISTUS ST VINCENT REGIONAL MEDICAL CENTER SPECIALIST IN MICROBIOLOGY; PETERSON EMMANUEL GUIMARÃES PAIXÃO; RODRIGO YUDI FUJIMOTO, CPATC.
Ano de publicação:	2025
Referência:	Aquaculture Internacional, v. 33, n. 525, 2025.
Conteúdo:	Nanoparticles have been applied across various sectors of industry and agriculture. However, concerns regarding environmental contamination and toxicity to target and non-target organisms are increasing. The combination of plant extracts with nanoparticles may enhance their intended effects while reducing overall toxicity. Despite this potential, notudies have evaluated the toxicity of a nanocomposite based on plant extract and silver nanoparticles (Ag Np) on the survival and hematological parameters of tambaqui (Colossoma macropomum). This study assessed the acute toxicity and hematological effects of a nanocomposite based on Terminalia catappa extract and Ag Np in tambaqui. Fish (3–5 g) were exposed to five concentrations of the nanocomposite (0.11, 0.22, 0.45, 0.87, and 1.73 mgL−1) in triplicate for 96 h. Moribund fish during exposure period and all survivors at the end of the experiment were subjected to hematological analysis. Mortality data were used to estimate the lethal concentration 50 (LC50) via the parametric probit method. Hematological data were analyzed using ANOVA and Tukey’s test. The nanocomposite exhibited an LC50 of 0.61 mgL−1, classifying it as a highly toxic for tambaqui. All fish exposed to 1.73 mgL−1 died within 2 h. Increases in glucose, plasma proteins, erythrocytes, hemoglobin, MCHC, and additionally, lymphocytopenia, neutrophilia, and monocytosis were observed at 0.87 mgL−1, reflecting a stress and acute respiratory toxicity. However, at lower concentrations (<0.45 mgL−1) no alterations were observed in hematological and biochemical parameters. In conclusion, the nanocomposite induces hematological altera- tions consistent with acute stress in high concentrations, nonetheless 0.45 mgL−1 is a critical threshold for fish survival.
Thesagro:	Piscicultura Aquicultura Tambaqui Peixe
NAL Thesaurus:	Fish Ornamental fish
Digital Object Identifier:	https://doi.org/10.1007/s10499-025-02211-5
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CPATC)