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dc.contributor.authorSILVA, T. F. da
dc.contributor.authorMESQUITA, J. X.
dc.contributor.authorLUZ, E. P. C. G.
dc.contributor.authorANDRADE, A. L.
dc.contributor.authorKOBS, H.
dc.contributor.authorTEIXEIRA, E. H.
dc.contributor.authorSOUZA FILHO, A. G. de
dc.contributor.authorFARIA, A. F. de
dc.contributor.authorMATTOS, A. L. A.
dc.contributor.authorANDRADE, F. K.
dc.contributor.authorVIEIRA, R. S.
dc.date.accessioned2026-01-13T20:48:59Z-
dc.date.available2026-01-13T20:48:59Z-
dc.date.created2026-01-13
dc.date.issued2025
dc.identifier.citationACS Omega, 10, 28969−28981, 2025.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1183546-
dc.descriptionPatients dealing with chronic wounds frequently experience persistent pain and a heightened risk of infection due to microbial contamination. To improve the quality of life for these patients while reducing treatment duration and costs, advanced wound dressings are being developed. This study aimed to develop a wound dressing from natural bacterial- derived cellulose fibers(BC) and calcium alginate (A), which were functionalized with silver- containing graphene oxide nanoparticles (GOAg). Carbon-based nanomaterials, such as GOAg, are recognized for their antimicrobial properties, noncytotoxic nature, and their strong ability to absorb exudate, which is crucial for controlling infections in dermal lesions. In vitro testing revealed that the BC-A-GOAg dressing possessed optimized characteristics, including a uniform distribution of GOAg nanoparticles within the polymeric blend of BC and A. When in direct contact with bacterial cells in suspension, the BC-A-GOAg dressing exhibited 74% antimicrobial activity against Staphylococcus aureus and 59% against Pseudomonas aeruginosa. Additionally, the antimicrobial BC-A-GOAg demonstrated no significant cytotoxicity to mouse fibroblast cells (L-929), maintaining 90.8% ± 5.2% cell viability after 48 h of exposure. Furthermore, the in vitro assessments showed that the BC-A-GOAg dressing could inhibit the activity of the myeloperoxidase enzyme, highlighting its effectiveness in reducing inflammation.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectBacterial Cellulose
dc.subjectCalcium Alginate Matrix
dc.titleAdvanced Foam Dressing of Modified Graphene Nanoparticles Loaded in Bacterial Cellulose/Calcium Alginate Matrix.
dc.typeArtigo de periódico
dc.subject.nalthesaurusGraphene oxide
riaa.ainfo.id1183546
riaa.ainfo.lastupdate2026-01-13
dc.identifier.doihttps://doi.org/10.1021/acsomega.5c00609
dc.contributor.institutionTHAMYRES FREIRE DA SILVA, FEDERAL UNIVERSITY OF CEARÁ
dc.contributor.institutionJACILANE XIMENES MESQUITA, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionERIKA PATRICIA CHAGAS GOMES LUZ, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionALEXANDRE LOPES ANDRADE, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionHENRY KOBS, UNIVERSITY OF FLORIDAeng
dc.contributor.institutionEDSON HOLANDA TEIXEIRA, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionANTÔNIO GOMES DE SOUZA FILHO, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionANDREIA FONSECA DE FARIA, UNIVERSITY OF FLORIDAeng
dc.contributor.institutionADRIANO LINCOLN ALBUQUERQUE MATTOS, CNPATeng
dc.contributor.institutionFÁBIA KARINE ANDRADE, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionRODRIGO SILVEIRA VIEIRA, FEDERAL UNIVERSITY OF CEARÁ.eng
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