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dc.contributor.authorBARROSO, W. da S.eng
dc.contributor.authorLUZ, E. P. C. G.eng
dc.contributor.authorMARQUES, L. S. M.eng
dc.contributor.authorCAVALCANTE, P. E. da S.eng
dc.contributor.authorSOUZA, F. F. P. deeng
dc.contributor.authorMATTOS, A. L. A.eng
dc.contributor.authorANDRADE, F. K.eng
dc.contributor.authorSILVA, A. L. C. daeng
dc.contributor.authorHIRATA, M. C.eng
dc.contributor.authorBOSCO, I.eng
dc.contributor.authorROCHA, D. N. daeng
dc.contributor.authorSOUZA, R. F. B. deeng
dc.contributor.authorSOUZA, F. C. B. deeng
dc.contributor.authorFERREIRA, J. R. M.eng
dc.contributor.authorVIEIRA, R. S.eng
dc.date.accessioned2026-01-14T13:48:42Z-
dc.date.available2026-01-14T13:48:42Z-
dc.date.created2026-01-14
dc.date.issued2025
dc.identifier.citationACS Applied Bio Materials, 8, 7011−7022, 2025.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1183553-
dc.descriptionThis study investigated the development of porous membranes based on a matrix of bacterial cellulose (BC) and sodium alginate (ALG) incorporated with proteins extracted from the tuna vitreous humor and complete conditioned medium (CCM) obtained from the in vitro culture of dental pulp stem cells. These bioactive components were integrated into BC-ALG membranes, which were then evaluated for morphology, physicochemical properties, in vitro cytotoxicity, and regenerative potential in vitro. The membranes exhibited high porosity (72% to 89%), and remarkable swelling capacity reaching up to 3376 ± 0.78% in 72 min, indicating excellent moisture retention essential for wound healing in vivo. Cytotoxicity assay showed that none of the formulations were cytotoxic to the tested mammalian cells, confirming their cytocompatibility. Membranes containing CCM showed enhanced cell viability at lower concentrations (500 μg/ mL and 250 μg/mL). In vitro scratch assays demonstrated that membranes with vitreous humor (VH) and CCM reduced scratch closure time from 18 to 12 h, suggesting their potential for accelerating skin regeneration. This work underscores the promise of using sustainable, waste-derived materials for creating bioactive membranes with applications in tissue engineering and regenerative medicine
dc.language.isoeng
dc.rightsopenAccess
dc.subjectBacterial cellulose
dc.subjectVitreous humor
dc.subjectBiological waste
dc.subjectWound dressings
dc.subjectSecretome
dc.titleProduction of Polymeric Membranes Functionalized with Vitreous Humor and Secretome from Dental Pulp Stem Cells for Use in Epithelial Regeneration.
dc.typeArtigo de periódico
riaa.ainfo.id1183553
riaa.ainfo.lastupdate2026-01-14
dc.identifier.doihttps://doi.org/10.1021/acsabm.5c00743
dc.contributor.institutionWALLADY DA SILVA BARROSO, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionERIKA PATRÍCIA CHAGAS GOMES LUZ, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionLIDYANE SOUTO MACIEL MARQUES, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionPAULO EDUARDO DA SILVA CAVALCANTE, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionFRANCISCO FÁBIO PEREIRA DE SOUZA, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionADRIANO LINCOLN ALBUQUERQUE MATTOS, CNPATeng
dc.contributor.institutionFABIA KARINE ANDRADE, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionANDRÉ LUÍS COELHO DA SILVA, FEDERAL UNIVERSITY OF CEARÁeng
dc.contributor.institutionMARIÁH CATIONI HIRATA, R-CRIO STEM CELLSeng
dc.contributor.institutionISADORA BOSCO, R-CRIO STEM CELLSeng
dc.contributor.institutionDANIEL NAVARRO DA ROCHA, R-CRIO STEM CELLSeng
dc.contributor.institutionRENATA FRANCIELLE BOMBALDI DE SOUZA, R-CRIO STEM CELLSeng
dc.contributor.institutionFERNANDA CARLA BOMBALDI DE SOUZA, R-CRIO STEM CELLSeng
dc.contributor.institutionJOSÉ RICARDO MUNIZ FERREIRA, R-CRIO STEM CELLSeng
dc.contributor.institutionRODRIGO SILVEIRA VIEIRA, FEDERAL UNIVERSITY OF CEARÁ.eng
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