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dc.contributor.authorGOULART, D. G.
dc.contributor.authorSOUZA, C. K.
dc.contributor.authorZANELLA, G. C.
dc.contributor.authorSNYDER, C. A.
dc.contributor.authorZANELLA, J. R. C.
dc.contributor.authorMARKIN, A.
dc.contributor.authorARRUDA, B.
dc.contributor.authorANDERSON, T. K.
dc.contributor.authorBAKER. A. L.
dc.date.accessioned2026-03-02T16:48:25Z-
dc.date.available2026-03-02T16:48:25Z-
dc.date.created2026-03-02
dc.date.issued2026
dc.identifier.citationInfluenza and Other Respiratory Viruses, v. 20, n. e70228, 2026.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1184840-
dc.descriptionABSTRACT Background The USDA influenza A virus in swine national surveillance plan identified an increase in the detection frequency of a group of swine 1A.1.1.3 hemagglutinin (HA) clade viruses. This change was associated with reassortment events that resulted in new neuraminidase (NA) gene pairings. We hypothesized that the new N1 genes improved the transmission efficiency of the virus. Methods We assessed the pathogenesis and transmission of four H1 1A.1.1.3 swine strains paired with different NA subtypes and lineages, all of which shared similar internal gene constellations. Results There was little variation in the titers of viral nasal shedding across the groups, and the different surface protein pairings had no effect on transmission efficiency. All IAV strains, reflecting both pre- and post-reassortment genetic patterns, were transmitted to naïve indirect contact pigs. Conclusions These data indicate that the combinations of 1A.1.1.3 HA with NA subtypes had little impact on transmission. These findings suggest that the increased detection of the H1 1A.1.1.3 clade in the United States was unlikely directly due to altered replication, transmission, or antigenic drift, but perhaps due to changes in population immunity resulting from differential vaccine use or prior exposure, variations in production practices, or ecological conditions.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectInfluenza virus
dc.subjectReassortment
dc.subjectPatogenese
dc.subjectPandemia
dc.subjectRearranjo genético
dc.titlePathogenesis and transmission of a reassorted H1 Influenza A virus detected in North American swine.
dc.typeArtigo de periódico
dc.subject.thesagroSuíno
dc.subject.thesagroZoonose
dc.subject.thesagroTransmissão de Doença
dc.subject.nalthesaurusSwine
dc.subject.nalthesaurusZoonoses
dc.subject.nalthesaurusVirus transmission
dc.subject.nalthesaurusPathogenesis
dc.subject.nalthesaurusPandemic
riaa.ainfo.id1184840
riaa.ainfo.lastupdate2026-03-02
dc.identifier.doihttps://doi.org/10.1111/irv.70228
dc.contributor.institutionDÉBORA B. GOULART, U.S. DEPARTMENT OF AGRICULTURE
dc.contributor.institutionARINE KUNZLER DE SOUZA, U.S. DEPARTMENT OF AGRICULTUREeng
dc.contributor.institutionGIOVANA CIACCI ZANELLA, IOWA STATE UNIVERSITYeng
dc.contributor.institutionCELESTE A. SNYDER, U.S. DEPARTMENT OF AGRICULTUREeng
dc.contributor.institutionJANICE REIS CIACCI ZANELLA, CNPSAeng
dc.contributor.institutionALEXEY MARKIN, U.S. DEPARTMENT OF AGRICULTUREeng
dc.contributor.institutionBAILEY ARRUDA, U.S. DEPARTMENT OF AGRICULTUREeng
dc.contributor.institutionTAVIS K. ANDERSON, U.S. DEPARTMENT OF AGRICULTUREeng
dc.contributor.institutionBAILEY ARRUDA, U.S. DEPARTMENT OF AGRICULTURE.eng
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