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dc.contributor.authorNICIURA, S. C. M.
dc.contributor.authorCORRÊA, L. G. P.
dc.contributor.authorIBELLI, A. M. G.
dc.contributor.authorBELLO, H. J. S.
dc.contributor.authorOKINO, C. H.
dc.contributor.authorCHAGAS, A. C. de S.
dc.date.accessioned2026-03-10T17:48:51Z-
dc.date.available2026-03-10T17:48:51Z-
dc.date.created2026-03-10
dc.date.issued2026
dc.identifier.citationBMC Veterinary Research, v. 22, article number 91, 2026.
dc.identifier.issn1746-6148
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1185255-
dc.descriptionHaemonchus contortus is a highly prevalent gastrointestinal nematode whose control is hindered by anthelmintic resistance. Worm replacement (WR), where a resistant parasite population is substituted for a susceptible one, was performed through an artificial infection of nematode-free ewes with a susceptible H. contortus isolate. The infected ewes were kept in a nematode-free paddock (total replacement—TR) or in a paddock naturally infested with resistant helminths (partial replacement—PR) and compared to untreated ewes kept in a naturally infested paddock (control—C). Lambs born in each group, over two breeding seasons, were evaluated from 63 to 189 days old and subjected to lifesaving anthelmintic treatments (AHt) with the combination of benzimidazole and levamisole when fecal egg counts (FEC) ≥ 10,000 and packed cell volume (PCV) ≤ 24% or when PCV ≤ 22%, and a Kaplan–Meier survival analysis of the AHt requirement was performed. Benzimidazole (F200Y) and levamisole (S168T) resistance-associated polymorphisms were genotyped in H. contortus every six months after WR.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectAllelic discrimination genotyping
dc.subjectAnthelmintic resistance
dc.subjectSurvival probability
dc.subjectWorm replacement
dc.titleResistance reversion after Haemonchus contortus replacement in a sheep flock: monitoring of benzimidazole and levamisole resistance-associated polymorphisms and impact on lamb survival.
dc.typeArtigo de periódico
dc.subject.thesagroHaemonchus Contortus
dc.subject.thesagroRebanho
dc.subject.thesagroOvelha
dc.subject.thesagroPolimorfismo
dc.subject.thesagroBenzimidazol
dc.subject.thesagroCordeiro
dc.subject.nalthesaurusAnthelmintics
dc.subject.nalthesaurusSheep
dc.subject.nalthesaurusBenzimidazole
dc.subject.nalthesaurusLevamisole
dc.subject.nalthesaurusPolymorphism
riaa.ainfo.id1185255
riaa.ainfo.lastupdate2026-03-10
dc.identifier.doihttps://doi.org/10.1186/s12917-025-05156-2
dc.contributor.institutionSIMONE CRISTINA MEO NICIURA, CPPSE; LORRANE GABRIELE PINHEIRO CORRÊA, UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO; ADRIANA MERCIA GUARATINI IBELLI, CPPSE; HORNBLENDA JOAQUINA SILVA BELLO, FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO; CINTIA HIROMI OKINO, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE.
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