Título:	Baccharis retusa and Baccharis reticularia as promising antivirals against Chikungunya virus and Herpes Simplex virus.
Autor:	PRÁ, I. D. GUTERRES, I. Z. RABELO, M. B. FRADE, A. C. M. LEANDRO, L. D. P. SCHULTE, L. G. CAMPANA, P. R. V. BARBOSA, M. OKI, Y. HEIDEN, G. FERNANDES, G. W. A. BRAGA, F. C. PÁDUA, R. M. FONGARO, G. SILVA, I. T.
Afiliación:	ISABELLA DAI PRÁ, UNIVERSIDADE FEDERAL DE SANTA CATARINA; IARA ZANELLA GUTERRES, UNIVERSIDADE FEDERAL DE SANTA CATARINA; MARIA BEATRIZ RABELO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; ALESSANDRA CAROLINE MONTES FRADE, UNIVERSIDADE FEDERAL DE MINAS GERAIS; LARISSA DANIELA PINTO LEANDRO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; LUISE GAUER SCHULTE, UNIVERSIDADE FEDERAL DE SANTA CATARINA; PRISCILLA RODRIGUES VALADARES CAMPANA, UNIVERSIDADE FEDERAL DE MINAS GERAIS; MILTON BARBOSA, UNIVERSIDADE FEDERAL DE MINAS GERAIS; YUMI OKI, UNIVERSIDADE FEDERAL DE MINAS GERAIS; GUSTAVO HEIDEN, CPACT; GERALDO WILSON AFONSO FERNANDES, UNIVERSIDADE FEDERAL DE MINAS GERAIS; FERNÃO CASTRO BRAGA, UNIVERSIDADE FEDERAL DE MINAS GERAIS; RODRIGO MAIA PÁDUA, UNIVERSIDADE FEDERAL DE MINAS GERAIS; GISLAINE FONGARO, UNIVERSIDADE FEDERAL DE SANTA CATARINA; IZABELLA THAÍS SILVA, UNIVERSIDADE FEDERAL DE SANTA CATARINA.
Año:	2026
Referencia:	Revista Brasileira de Farmacognosia, v. 36, n. 7, 2026.
Descripción:	Abstratc: Natural products play a vital role in the development of antiviral drugs, particularly against herpes simplex viruses (HSV-1 and HSV-2), which infect up to 90% of the global population. Current treatments are limited, and increasing resistance to acyclovir complicates disease management. Chikungunya fever, caused by the chikungunya virus, which accounted for 127,000 cases in Brazil in 2023, lacks an approved vaccine or specific antiviral treatment. Some substances already isolated from plants of the Baccharis genus, such as trichothecenes, flavonoids and terpenes, showed the pharmacological potential of these species. In this context, the study aimed to evaluate the cytotoxic activity using the sulforhodamine B assay, as well as the antiviral potential of extracts and fractions from Baccharis species against chikungunya virus and HSV-1 (KOS and 29-R strains) using the plaque reduction assay. After evaluating the antiviral activity against chikungunya virus, it was observed that the extracts of Baccharis retusa DC. and B. reticularia DC., Asteraceae, were the most active, with IC50 values of 2.9 and 3.6 μg/ml, respectively, presenting SI values of 124 and 122, respectively. Regarding antiherpetic activity, B. retusa and B. reticularia extracts presented IC50 values of 7.3 and 15.9 μg/ml against KOS strain, and 9.9 and 18.9 μg/ml against the 29-R strain, with SI values of 50.23 and 27.68 against the KOS strain, and 37.05 and 24.33 against the 29-R strain, respectively. Dereplication of B. retusa and B. reticularia extracts by UPLC-DAD-ESI–MS/MS discloses the presence of chlorogenic acid derivatives and flavanones or dihydroflavonols in both species.
Thesagro:	Flavonóide
NAL Thesaurus:	Chlorogenic acid Flavonoids
Palabras clave:	Produtos naturais Atividade antiviral Derivados do ácido clorogênico Antiviral activity Natural products
DOI:	https://doi.org/10.1007/s43450-025-00719-8
Tipo de Material:	Artigo de periódico
Acceso:	openAccess
Aparece en las colecciones:	Artigo em periódico indexado (CPACT)