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dc.contributor.authorURDAPILLETA, A. A. A.
dc.contributor.authorALFANI, A. de O. S.
dc.contributor.authorBARROSO, D. H.
dc.contributor.authorVINECKY, F.
dc.contributor.authorBANDEIRA, S. da G. A. V.
dc.contributor.authorANDRADE, A. C.
dc.contributor.authorMELO, J. A. T.
dc.contributor.authorBASTOS, I. M. D.
dc.contributor.authorSAMPAIO, R. N. R.
dc.date.accessioned2026-04-30T14:48:23Z-
dc.date.available2026-04-30T14:48:23Z-
dc.date.created2026-04-30
dc.date.issued2024
dc.identifier.citationBiomedicines, v. 12, n. 10, 2227, 2024.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1186524-
dc.descriptionBackground: Mucosal leishmaniasis (ML) is a deforming type of American Tegumentary Leishmaniasis caused by Leishmania (Viannia) braziliensis that frequently does not respond to treatment. Despite its relapsing clinical course, few parasites are usually found in mucosal lesions. Host and parasite factors may be responsible for this paradox in the pathogenesis of the disease, allowing for both a low parasite burden and the inability of the host to clear and eliminate the disease. Methods and results: In this work, we present a clinical case of relapsing ML that was treated for 25 years without success with SbV, N-methyl glucamine, sodium stibogluconate, amphotericin B deoxycholate, gabromycin, antimonial plus thalidomide, liposomal amphotericin B, Leishvacin (a vaccine made in Brazil) and miltefosine. In a comparative analysis using nanoscale liquid chromatography coupled with tandem mass spectrometry of protein extracts of L. (V.) braziliensis promastigotes isolated from the patient and from the reference strain (MHOM/BR/94/M15176), we observed increases in ATPase and HSP70 protein levels in the parasite. We also observed an impairment in the production of hydrogen peroxide by peripheral mononuclear blood monocytes (PBMCs), as assessed by the horseradish peroxidase-dependent oxidation of phenol red. Conclusions: We hypothesise that these parasite molecules may be linked to the impairment of host parasiticidal responses, resulting in Leishmania persistence in ML patients.
dc.language.isoeng
dc.rightsopenAccess
dc.titleTreatment of refractory mucosal leishmaniasis is associated with parasite overexpression of HSP70 and ATPase and reduced host hydrogen peroxide production (brief report).
dc.typeArtigo de periódico
dc.subject.nalthesaurusLeishmaniasis
dc.subject.nalthesaurusDrug resistance
dc.subject.nalthesaurusHydrogen peroxide
dc.format.extent211 p.
riaa.ainfo.id1186524
riaa.ainfo.lastupdate2026-04-30
dc.identifier.doihttps://doi.org/10.3390/biomedicines12102227
dc.contributor.institutionADA AMÁLIA AYALA URDAPILLETA, UNIVERSIDADE DE BRASÍLIA; ADRIANA DE OLIVEIRA SANTOS ALFANI, UNIVERSIDADE DE BRASÍLIA; DANIEL HOLANDA BARROSO, UNIVERSIDADE DE BRASÍLIA; FELIPE VINECKY, UNIVERSIDADE FEDERAL DE LAVRAS; SUZANA DA GLÓRIA AMARAL VAZ BANDEIRA, UNIVERSIDADE DE BRASÍLIA; ALAN CARVALHO ANDRADE, CENARGEN; JORGE ALEX TAQUITA MELO, CENARGEN; IZABELA MARQUES DOURADO BASTOS, UNIVERSIDADE DE BRASÍLIA; RAIMUNDA NONATA RIBEIRO SAMPAIO, UNIVERSIDADE DE BRASÍLIA.
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