Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1187624
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dc.contributor.authorARENA, A. C.
dc.contributor.authorJORGE, B. C.
dc.contributor.authorMANOEL, B. de M.
dc.contributor.authorSTEIN, J.
dc.contributor.authorKASSUYA, C. A. L.
dc.contributor.authorHISANO, H.
dc.date.accessioned2026-06-16T17:48:39Z-
dc.date.available2026-06-16T17:48:39Z-
dc.date.created2026-06-16
dc.date.issued2026
dc.identifier.citationReproductive Toxicology, v. 140, article 109158, 2026.
dc.identifier.issn0890-6238
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1187624-
dc.descriptionAbstract: Micro- and nanoplastics (MNPs) have been increasingly detected in human tissues, including the placenta and, more recently, the brain. Their capacity to cross biological barriers such as the placenta and the blood–brain barrier raises significant concern for sexually dimorphic neurodevelopment. Brain sexual differentiation, orchestrated by steroid hormones, neuroimmune signaling, and epigenetic programming during early life, represents one of the most hormonally sensitive and developmentally critical targets of environmental disruption. In this narrative review, we synthesize evidence positioning MNPs as potential endocrine and epigenetic disruptors that may reprogram hypothalamic circuits governing reproduction and socioemotional behavior within a DOHaD framework. Evidence is stronger in animal and cellular models, implicating oxidative stress, neuroinflammation, apoptosis, and disrupted neurotransmission as central mechanisms; however, sex-specific endpoints remain underexplored and human data are still limited. This review adds a novel integrative perspective by focusing on sexually dimorphic hypothalamic nuclei and by outlining testable, sex-informed hypotheses. We highlight key methodological priorities for future research, including environmentally relevant exposures, explicit consideration of sex as a biological variable, multi-omics approaches, and longitudinal designs.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectBrain sexual differentiation
dc.subjectDOHaD
dc.subjectEndocrine disruption
dc.subjectNanoplastics
dc.subjectMicroplastics
dc.subjectNanoplásticos
dc.subjectMicroplásticos
dc.subjectDimorfismo sexual
dc.titleMicro- and nanoplastics and brain sexual differentiation: an emerging neurodevelopmental threat within the DOHaD framework.
dc.typeArtigo de periódico
dc.subject.nalthesaurusSexual dimorphism
dc.subject.nalthesaurusBrain
dc.subject.nalthesaurusBlood-brain barrier
dc.subject.nalthesaurusEpigenetics
dc.subject.nalthesaurusNeurodevelopment
riaa.ainfo.id1187624
riaa.ainfo.lastupdate2026-06-16
dc.identifier.doihttps://doi.org/10.1016/j.reprotox.2026.109158
dc.contributor.institutionARIELLE CRISTINA ARENA, UNIVERSIDADE ESTADUAL DE SÃO PAULO; BÁRBARA CAMPOS JORGE, UNIVERSITY OF MISSISSIPPI MEDICAL CENTER; BEATRIZ DE MATOS MANOEL, UNIVERSIDADE ESTADUAL DE SÃO PAULO; JULIA STEIN, UNIVERSIDADE ESTADUAL DE SÃO PAULO; CÂNDIDA APARECIDA LEITE KASSUYA, UNIVERSIDADE FEDERAL DA GRANDE DOURADOS; HAMILTON HISANO, CNPMA.
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