Título:	Ecodesign of collagen extraction from tilapia skin: an integrated economic–environmental framework for process and product improvement at the laboratory scale.
Autoria:	QUEIROZ, J. D. G. de SÁ FILHO, E. B. de MENEZES, M. do L. L. R. CÂMARA, G. I. F. SOUZA FILHO, M. de S. M. de SILVA NETO, R. M. da LEITAO, R. C. FIGUEIREDO, M. C. B. de
Afiliação:	JOHNNY DAVID GOMES DE QUEIROZ, UNIVERSIDADE ESTADUAL DO CEARÁ; EDNALDO BENÍCIO DE SÁ FILHO, UNIVERSIDADE FEDERAL DO CEARÁ; MARIA DO LIVRAMENTO LINHARES RODRIGUES MENEZES, UNIVERSIDADE ESTADUAL DO CEARÁ; GABRIELA IBIAPINA FIGUEIREDO CÂMARA, INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DO CEARÁ; MEN DE SA MOREIRA DE SOUZA FILHO, CNPAT; RAIMUNDO MARCELINO DA SILVA NETO, CNPAT; RENATO CARRHA LEITAO, CNPAT; MARIA CLEA BRITO DE FIGUEIREDO, CNPAT.
Ano de publicação:	2026
Referência:	The International Journal of Life Cycle Assessment, v. 31, n. 1-3, 37, Mar. 2026.
Conteúdo:	Purpose: Tilapia skin, a filleting by product, can be used to extract collagen (CTS) for bio-based films and hydrogels. This study performs the first ex-ante environmental and economic assessment of CTS, evaluating two pathways for these applications, with the aim of guiding the selection of one of these pathways for future investments in pilot plants or their redesign. Methods: Two pathways for extracting 1 kg/year of CTS were modeled at a pilot scale using laboratory data in SuperPro Designer: acid-soluble (ASC) and pepsin-soluble (PSC). Total costs and the Product Environmental Footprint were combined in contribution and scenario analyses, considering the mass and economic allocation in tilapia production and filleting. The contributions of unit processes to the impacts and costs of CTS were shown in a proportionality graph with a threshold line of relevance; only the critical points above it were prioritized to identify alternatives to reduce environmental and/or economic impacts. An optimal pathway was selected, considering uncertainty. The impacts of CTS (optimal pathway) were then compared to those of cellulose, starch, and polyacrylamide, used in films and hydrogels. The minimum selling price (MSP), calculated as annual costs per production, was also compared to surrogate market prices. These comparisons included sensitivity and uncertainty analyses. Results and discussion: The CTS performance study shows that collagen has greater environmental and price impacts than cornstarch, cellulose, and polyacrylamide, even with 90% less CTS, in both allocation criteria and in most impact categories. The comparison between ASC and PSC after improvements reveals that ASC outperforms PSC, leading to its selection. In both pathways and criteria, the main critical points above the relevance threshold and close to the proportionality line are sodium chloride, ultrapure water, acetic acid, and ethanol. For these points, the most effective alternatives are replacing dialysis with diafiltration and adjusting the acetic acid concentration, along with reducing reaction time, temperature, and yield. Conclusions: Recommendations were provided for redesigning the CTS production process and its targeted application, highlighting potential improvements such as the use of electrodialysis in the purification stage, the removal of the lipid extraction step or the replacement of ethanol with butyl alcohol, as well as the evaluation of applications in the biomedical sector. Learnings from this study allowed the proposition of a novel integrated framework for improving technological pathways and targeting product application based on techno-economic and environmental impact criteria at technology readiness level 5. This framework may be applied to assess and improve other technologies on a laboratory scale.
Thesagro:	Impacto Ambiental Análise Econômica Tilápia Nilótica Oreochromis Niloticus
NAL Thesaurus:	Life cycle assessment Attributional life cycle assessment Collagen Byproduct utilization Co-product allocation
Palavras-chave:	Indústria de Pescado Economic evaluation Ecodesign Colágeno de pele de tilápia Avaliação do ciclo de vida ex ante Análise técnico-econômica Avaliação econômico-ambiental integrada Nível de maturidade tecnológica 5 Ampliação de escala de processo Modelagem de processo em escala-piloto Seleção de rota tecnológica Redesenho de processo Pontos críticos econômico-ambientais Pegada ambiental do produto Preço mínimo de venda Tilapia skin collagen Ex-ante life cycle assessment Techno-economic analysis Integrated environmental-economic assessment Technology readiness level 5 Process upscaling Pilot-scale process modeling Technological pathway selection Process redesign Environmental-economic hotspots Product Environmental Footprint Minimum selling price
ISSN:	1614-7502
Digital Object Identifier:	https://doi.org/10.1007/s11367-026-02576-6
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPAT)