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dc.contributor.authorSILVA, A. B. da
dc.contributor.authorPINTO, F. C. L.
dc.contributor.authorSILVEIRA, E. R.
dc.contributor.authorPAULO, T. de F.
dc.contributor.authorWILKE, D. V.
dc.contributor.authorFERREIRA, E. G.
dc.contributor.authorCOSTA-LOTUFO, L. V.
dc.contributor.authorCANUTO, K. M.
dc.contributor.authorMARINHO-FILHO, J. D. B.
dc.contributor.authorBARROS, A. B.
dc.contributor.authorNUZZO, G.
dc.contributor.authorFONTANA, A.
dc.contributor.authorMONTEIRO, N. K. V.
dc.contributor.authorPESSOA, O. D. L.
dc.date.accessioned2026-08-04T18:49:01Z-
dc.date.available2026-08-04T18:49:01Z-
dc.date.created2026-08-04
dc.date.issued2026
dc.identifier.citationJournal of Natural Products, v. 89, n. 1, p. 304−312, Jan. 2026.
dc.identifier.issn1520-6025
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1188916-
dc.descriptionFive new rifamycin derivatives, named salinirifamycins A–E (1–5), were isolated from a Brazilian marine Salinispora arenicola (BRA-213) strain extract. The structures of the new rifamycins were elucidated using a combination of NMR, IR, UV, and MS spectroscopic techniques, quantum-chemical calculations (DFT-calculated 13C NMR chemical shifts and DP4+ probability analysis), and comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1, 2, and 4 displayed antibacterial activity against Staphylococcus aureus and Enterococcus faecalis with MIC values ranging from 2.0 to 125.0 μg/mL, whereas 5 exhibited an MIC of 0.02 μg/mL to S. aureus, similar to the positive control rifampicin (MIC 0.03 μg/mL).
dc.language.isoeng
dc.rightsopenAccess
dc.subjectSalinirifamicinas A–Eeng
dc.subjectSalinispora arenicola BRA-213eng
dc.subjectActinomiceto marinhoeng
dc.subjectDerivados de rifamicina Seng
dc.subjectProdutos naturais marinhoseng
dc.subjectElucidação estruturaleng
dc.subjectCálculos químico-quânticoseng
dc.subjectAnálise de probabilidade DP4+eng
dc.subjectAtividade antibacterianaeng
dc.subjectSalinirifamycins A–Eeng
dc.subjectMarine actinomyceteeng
dc.subjectRifamycin S derivativeseng
dc.subjectMarine natural productseng
dc.subjectStructure elucidationeng
dc.subjectQuantum-chemical calculationseng
dc.subjectDP4+ probability analysiseng
dc.subjectAntibacterial activityeng
dc.titleSalinirifamycins A−E: rifamycin S derivatives from the Brazilian marine actinomycete Salinispora arenicola.
dc.typeArtigo de periódico
dc.subject.thesagroAntibióticoeng
dc.subject.thesagroBactériaeng
dc.subject.thesagroBiologia Aquáticaeng
dc.subject.thesagroFermentaçãoeng
dc.subject.nalthesaurusRifamycins
dc.subject.nalthesaurusSecondary metaboliteseng
dc.subject.nalthesaurusStaphylococcus aureus subsp. aureuseng
dc.subject.nalthesaurusMinimum inhibitory concentrationeng
dc.subject.nalthesaurusNuclear magnetic resonance spectroscopyeng
dc.subject.nalthesaurusMass spectrometryeng
dc.subject.nalthesaurusCircular dichroism spectroscopyeng
dc.subject.nalthesaurusEnterococcus faecaliseng
riaa.ainfo.id1188916
riaa.ainfo.lastupdate2026-08-04
dc.identifier.doihttps://doi.org/10.1021/acs.jnatprod.5c01381
dc.contributor.institutionALISON BATISTA DA SILVA, UNIVERSIDADE FEDERAL DO CEARÁ
dc.contributor.institutionFRANCISCO DAS CHAGAS LIMA PINTO, UNIVERSIDADE FEDERAL DO CEARÁeng
dc.contributor.institutionEDILBERTO ROCHA SILVEIRA, UNIVERSIDADE FEDERAL DO CEARÁeng
dc.contributor.institutionTÉRCIO DE FREITAS PAULO, UNIVERSIDADE FEDERAL DO CEARÁeng
dc.contributor.institutionDIEGO VERAS WILKE, UNIVERSIDADE FEDERAL DO CEARÁeng
dc.contributor.institutionELTHON GOIS FERREIRA, UNIVERSIDADE FEDERAL DO CEARÁeng
dc.contributor.institutionLETICIA VERAS COSTA LOTUFO, UNIVERSIDADE DE SÃO PAULOeng
dc.contributor.institutionKIRLEY MARQUES CANUTO, CNPATeng
dc.contributor.institutionJOSÉ DELANO BARRETO MARINHO FILHO, UNIVERSIDADE FEDERAL DO DELTA DO PARNAÍBAeng
dc.contributor.institutionAYSLAN BATISTA BARROS, UNIVERSIDADE FEDERAL DO DELTA DO PARNAÍBAeng
dc.contributor.institutionGENOVEFFA NUZZO, ISTITUTO DI CHIMICA BIOMOLECOLAREeng
dc.contributor.institutionANGELO FONTANA, ISTITUTO DI CHIMICA BIOMOLECOLAREeng
dc.contributor.institutionNORBERTO DE KÁSSIO VIEIRA MONTEIRO, UNIVERSIDADE FEDERAL DO CEARÁeng
dc.contributor.institutionOTÍLIA DEUSDÊNIA LOIOLA PESSOA, UNIVERSIDADE FEDERAL DO CEARÁ.eng
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