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dc.contributor.authorSILVA, A. R. P. da
dc.contributor.authorCOSTA, M. do S.
dc.contributor.authorARAÚJO, N. J. S.
dc.contributor.authorALENCAR, G. G.
dc.contributor.authorMOURA, T. F.
dc.contributor.authorFONSECA, V. J. A.
dc.contributor.authorSANTOS, A. T. L. dos
dc.contributor.authorMORAIS-BRAGA, M. F. B.
dc.contributor.authorSOUZA, E. O. de
dc.contributor.authorTAVARES, J. F.
dc.contributor.authorRIBEIRO, P. R. V.
dc.contributor.authorANDRADE-PINHEIRO, J. C.
dc.contributor.authorCOUTINHO, H. D. M.
dc.date.accessioned2026-08-07T12:47:04Z-
dc.date.available2026-08-07T12:47:04Z-
dc.date.created2026-08-07
dc.date.issued2026
dc.identifier.citationBiomedical Chromatography, v. 40, n. 7, e70509, July 2026.
dc.identifier.issn1099-0801
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1189019-
dc.descriptionThe development of antifungal resistance is a complex process that involves the interaction between hosts, drugs, and microbial factors, all of which contribute to therapeutic ineffectiveness. For this reason, studies on natural products as possible therapeutic alternatives are increasingly necessary in order to gain a better understanding of plant compounds that may be more effective in treating infections caused by fungal pathogens. In this context, this study aimed to investigate the antifungal potential of the saponin-enriched fraction of the Sarcomphalus joazeiro species against the Candida albicans, Candida tropicalis, and Candida krusei strains. The selection of this species for study is due to its rich phytochemical composition and the vast traditional knowledge of its medicinal properties. The fraction obtained from the stem bark of S. joazeiro was analyzed by UPLC-QTOF-MS/MS, in which compounds such as triterpenoids, flavonoids, acids, and saponins were identified. Therefore, the results obtained in this study contribute to understanding the antifungal potential of the S. joazeiro species fraction against fungal infections, especially those caused by Candida spp.
dc.language.isopor
dc.rightsopenAccess
dc.subjectSarcomphalus joazeiro
dc.subjectUPLC-QTOF-MS/MS
dc.subjectFração enriquecida em saponinas
dc.subjectAtividade antifúngica
dc.subjectCasca do caule de Sarcomphalus joazeiro
dc.subjectModulação da atividade do fluconazol
dc.subjectAntagonismo com fluconazol
dc.subjectSaponin enriched fraction
dc.subjectAntifungal activity
dc.subjectSarcomphalus joazeiro stem bark
dc.subjectFluconazole activity modulation
dc.subjectFluconazole antagonism
dc.titleUPLC-QTOF-MS/MS and antifungal activity of a fraction enriched in saponins from Sarcomphalus joazeiro against Candida spp.
dc.typeArtigo de periódico
dc.subject.thesagroSaponina
dc.subject.thesagroFlavonóide
dc.subject.thesagroPlanta Medicinal
dc.subject.thesagroCândida Albicans
dc.subject.thesagroZiziphus Joazeiro
dc.subject.nalthesaurusSaponins
dc.subject.nalthesaurusFlavonoids
dc.subject.nalthesaurusAntifungal agents
dc.subject.nalthesaurusCandida tropicalis
dc.subject.nalthesaurusCandida krusei
dc.subject.nalthesaurusFluconazole
dc.subject.nalthesaurusUltra-performance liquid chromatography
dc.subject.nalthesaurusMass spectrometry
dc.subject.nalthesaurusMinimum inhibitory concentration
dc.subject.nalthesaurusBark
riaa.ainfo.id1189019
riaa.ainfo.lastupdate2026-08-07
dc.identifier.doihttps://doi.org/10.1002/bmc.70509
dc.contributor.institutionANA RAQUEL PEREIRA DA SILVA, UNIVERSIDADE ESTADUAL DO CEARÁ; MARIA DO SOCORRO COSTA, UNIVERSIDADE ESTADUAL DO CEARÁ; NARA JULIANA SANTOS ARAÚJO, UNIVERSIDADE FEDERAL DO CARIRI; GABRIEL GONÇALVES ALENCAR, UNIVERSIDADE REGIONAL DO CARIRI; TALYSSON FELISMINO MOURA, UNIVERSIDADE REGIONAL DO CARIRI; VICTOR JUNO ALENCAR FONSECA, UNIVERSIDADE REGIONAL DO CARIRI; ANTÔNIA THASSYA LUCAS DOS SANTOS, UNIVERSIDADE REGIONAL DO CARIRI; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, UNIVERSIDADE REGIONAL DO CARIRI; ERLÂNIO OLIVEIRA DE SOUZA, FACULDADE DE TECNOLOGIA DO CARIRI; JOSEAN FECHINE TAVARES, UNIVERSIDADE FEDERAL DA PARAÍBA; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; JACQUELINE COSMO ANDRADE-PINHEIRO, UNIVERSIDADE FEDERAL DO CARIRI; HENRIQUE DOUGLAS MELO COUTINHO, UNIVERSIDADE REGIONAL DO CARIRI.
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