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dc.contributor.authorVESCHI, J. L. A.
dc.contributor.authorDUTRA, I. S.
dc.contributor.authorALVES, M. A. B.
dc.contributor.authorFERNANDEZ-MIYAKAWA, M. E.
dc.contributor.authorPERRI, S. H. V.
dc.contributor.authorUZAL, F. A.
dc.date.accessioned2024-07-17T12:55:20Z-
dc.date.available2024-07-17T12:55:20Z-
dc.date.created2008-10-27
dc.date.issued2008
dc.identifier.citationIn: INTERNATIONAL CONFERENCE ON GOATS, 9.; REUNIÓN NACIONAL SOBRE CAPRINOCULTURA, 23, 2008, Querétaro, México. Sustainable goat production: challenges an opportunities of small and large enterprises; proceedings. Querétaro: International Goat Association, 2008.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/160900-
dc.descriptionEnterotoxemia in sheep and in goats is caused by the effects of the epsilon toxin of C/ostridium perfringens type D, being considered the main infectious cause of mortality in those animal species. The main prophylactic measures include adequate nutritional management and vaccination of ali animais using vaccines of high immunogenic power. Six commercial vaccines containing in its formulation the epsilon toxoid of C. perfringens type D were sorogically evaluated. Eighty four female goat kids, whose mothers had no previous vaccination history against clostridioses were used. They were divided into six groups of 14 animais each. The animais of the control group didn't receive any vaccine dose and the animais from the groups 1 to 5 received two vaccine doses, The first vaccine dose was applied at 45 days of life (day zero) and the second dose at 75 days (30 days after the first dose). Blood samples were collected from the goat kids at the days zero, 30, 60, 90, 120 and 150 after the beginning of the experiment, in order to evaluate the immunologic response. The Indirect ELlSA technique was used for the quantification of the antibodies against epsilon toxin in the samples of blood serum of the animais. In day zero, no animal presented titre considered protector. The largest number of animais considered protected was found at day 60, in response to the two initial doses of the vaccine (days O and 30, first and second doses, respectively). Only tive animaIs which received the vaccine 1 and one animal which received the vaccine 3 stayed wilh titres of antibodies considered up to 150 days after the first vaccine dose. Based on the results, it was concluded lhat the evaluated vaccines showed small amount of epsilon toxoid in the commercial formulations, a crucial fact for lhe low efficiency of. the vaccines. For commercial reasons, the vaccines against the clostridioses present versatile formulations, with several toxoid types, used for various animal species, which certainly contributed to reduce their effectiveness in preventing the iIInesses caused by the clostridia or their toxins.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectAvaliação comercial
dc.subjectClostridium perfringens type D
dc.subjectEpsilon toxin
dc.titleSorological evaluation of commercial vaccines against enterotoxemia in goats.
dc.typeArtigo em anais e proceedings
dc.subject.thesagroProdução animal
dc.subject.thesagroDoença
dc.subject.thesagroCaprino
dc.subject.thesagroEnterotoxemia
dc.subject.thesagroImunologia
dc.subject.thesagroToxina
dc.subject.thesagroVacina
dc.subject.nalthesaurusImmune response
dc.subject.nalthesaurusVaccination
riaa.ainfo.id160900
riaa.ainfo.lastupdate2024-07-17
dc.contributor.institutionJOSIR LAINE APARECIDA VESCHI, CPATSA; IVERALDO S. DUTRA, UNIVERSIDADE ESTADUAL PAULISTA; MARIA ANGÉLICA B. ALVES, FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO; MARIANO E. FERNANDEZ-MIYAKAWA, CALIFORNIA'S COLLEGE TOWN; SILVIA HELENA V. PERRI, UNIVERSIDADE ESTADUAL PAULISTA; FRANCISCO A. UZAL, CALIFORNIA'S COLLEGE TOWN.
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