Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/681123
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dc.contributor.authorANDRADE-NETO, V. F. dept_BR
dc.contributor.authorPOHLIT, A. M.pt_BR
dc.contributor.authorPINTO, A. C. S.pt_BR
dc.contributor.authorSILVA, E. C. C.pt_BR
dc.contributor.authorNOGUEIRA, K. L.pt_BR
dc.contributor.authorMELO, M. R. S.pt_BR
dc.contributor.authorHENRIQUE, M. C.pt_BR
dc.contributor.authorAMORIM, R. C. N.pt_BR
dc.contributor.authorSILVA, L. F. R.pt_BR
dc.contributor.authorCOSTA, M. R. F.pt_BR
dc.contributor.authorNUNOMURA, R. C. S.pt_BR
dc.contributor.authorNUNOMURA, S. M.pt_BR
dc.contributor.authorALECRIM, W. D.pt_BR
dc.contributor.authorALECRIM, M. das G. C.pt_BR
dc.contributor.authorCHAVES, F. C. M.pt_BR
dc.contributor.authorVIEIRA, P. P. R.pt_BR
dc.date.accessioned2015-01-07T08:23:46Z-
dc.date.available2015-01-07T08:23:46Z-
dc.date.created2007-09-18pt_BR
dc.date.issued2007pt_BR
dc.identifier.citationMemórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 359-365, jun. 2007.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/681123pt_BR
dc.descriptionIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectIsolação in vitropt_BR
dc.titleIn vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2015-01-07T08:23:46Zpt_BR
dc.subject.thesagroPlantapt_BR
dc.subject.nalthesaurusAmazoniapt_BR
dc.subject.nalthesaurusPlasmodium falciparumpt_BR
dc.subject.nalthesaurusmalariapt_BR
riaa.ainfo.id681123pt_BR
riaa.ainfo.lastupdate2015-01-06pt_BR
dc.contributor.institutionValter F. de Andrade-Neto, Inpa; Adrian M. Pohlit, Inpa; Ana Cristina S. Pinto, Inpa/Ufam; Ellen Cristina C. Silva, Inpa/Ufam; Karla L. Nogueira, Inpa/CEFET-AM; Márcia R.S. Melo, Inpa/FMTM; Marycleuma C. Henrique, Inpa/Ufam; Rodrigo C.N. Amorim, Inpa/Ufam; Luis Francisco R. Silva, FMTM; Mônica R.F. Costa, FMTM; Rita C.S. Nunomura, Inpa; Sergio M. Nunomura, Inpa; Wilson D. Alecrim, FMTM; Maria das Graças C. Alecrim, Inpa/UniNilton Lins; Francisco Célio Maia Chaves, CPAA; Pedro Paulo R. Vieira, UEA.pt_BR
Appears in Collections:Artigo em periódico indexado (CPAA)

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