Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/697051
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dc.contributor.authorALVES, C. C. de S.
dc.contributor.authorAZEVEDO, A. L. S.
dc.contributor.authorRODRIGUES, M. F.
dc.contributor.authorMACHADO, R. P.
dc.contributor.authorSOUZA, M. A.
dc.contributor.authorMACHADO, M. A.
dc.contributor.authorTEIXEIRA, H. C.
dc.contributor.authorFERREIRA, A. P.
dc.date.accessioned2024-02-16T18:32:27Z-
dc.date.available2024-02-16T18:32:27Z-
dc.date.created2010-04-20
dc.date.issued2009
dc.identifier.citationComparative Immunology, Microbiology and Infectious Discases, v. 32, n. 6, p. 513-525, 2009.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/697051-
dc.descriptionParacoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-γ production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-γ. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-γ and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectIFN-y
dc.subjectIL-10
dc.subjectAntibody response
dc.subjectIntrathoracic route
dc.titleCellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice.
dc.typeArtigo de periódico
dc.subject.nalthesaurusParacoccidioides brasiliensis
riaa.ainfo.id697051
riaa.ainfo.lastupdate2024-02-16
dc.identifier.doihttps://doi.org/10.1016/j.cimid.2008.07.006
dc.contributor.institutionCAIO CÉSAR DE SOUZA ALVES, UFJF
dc.contributor.institutionANA LUISA SOUSA AZEVEDO, CNPGLeng
dc.contributor.institutionMICHELE F. RODRIGUES, UFJFeng
dc.contributor.institutionRACHEL P. MACHADO, UFJFeng
dc.contributor.institutionSUPREMAeng
dc.contributor.institutionMARIA A. SOUZA, UFJFeng
dc.contributor.institutionMARCO ANTONIO MACHADO, CNPGLeng
dc.contributor.institutionHENRIQUE C. TEIXEIRA, UFJFeng
dc.contributor.institutionANA P. FERREIRA, UFJF.eng
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