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dc.contributor.authorORIÁ, R. B.pt_BR
dc.contributor.authorPATRICK, P. D.pt_BR
dc.contributor.authorORIÁ, M. O. B.pt_BR
dc.contributor.authorLORNTZ, B.pt_BR
dc.contributor.authorTHOMPSON, M. R.pt_BR
dc.contributor.authorAZEVEDO, O. G. R.pt_BR
dc.contributor.authorLOBO, R. N. B.pt_BR
dc.contributor.authorPINKERTON, R. F.pt_BR
dc.contributor.authorGUERRANT, R. L.pt_BR
dc.contributor.authorLIMA, A. A. M.pt_BR
dc.date.accessioned2011-04-10T11:11:11Zpt_BR
dc.date.available2011-04-10T11:11:11Zpt_BR
dc.date.created2010-07-07pt_BR
dc.date.issued2010pt_BR
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 43, n. 3, p. 249-256, Mar. 2010.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/857019pt_BR
dc.descriptionA series of studies have shown that the heavy burdens of diarrheal diseases in the first 2 formative years of life in children living in urban shanty towns have negative effects on physical and cognitive development lasting into later childhood. We have shown that APOE4 is relatively common in shanty town children living in Brazil (13.4%) and suggest that APOE4 has a protective role in cognitive development as well as weight-for-height in children with heavy burdens of diarrhea in early childhood (64/123; 52%), despite being a marker for cognitive decline with Alzheimer?s and cardiovascular diseases later in life. APOE2 frequency was higher among children with heaviest diarrhea burdens during the first 2 years of life, as detected by PCR using the restriction fragment length polymorphism method, raising the possibility that ApoE-cholesterol balance might be critical for growth and cognitive development under the stress of heavy diarrhea burdens and when an enriched fat diet is insufficient. These findings provide a potential explanation for the survival advantage in evolution of genes, which might raise cholesterol levels during heavy stress of diarrhea burdens and malnutrition early in life.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2019-09-23T11:11:11Zpt_BR
dc.subject.nalthesaurusApolipoprotein Ept_BR
dc.subject.nalthesaurusMalnutritionpt_BR
dc.subject.nalthesaurusDiarrheapt_BR
dc.subject.nalthesaurusChildrenpt_BR
riaa.ainfo.id857019pt_BR
riaa.ainfo.lastupdate2019-09-23 -03:00:00pt_BR
dc.contributor.institutionDepartamento de Morfologia e Instituto de Biomedicina do Semi-árido Brasileiro (IBISAB), Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CEpt_BR
dc.contributor.institutionKluge Children’s Rehabilitation and Research Center, University of Virginia, Charlottesville, VA, USAeng
dc.contributor.institutionDepartamento de Enfermagem, Universidade Federal do Ceará, Fortaleza, CEeng
dc.contributor.institutionInstituto de Biomedicina do Semi-árido Brasileiro (IBISAB), Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CEeng
dc.contributor.institutionCenter for Global Health, School of Medicineeng
dc.contributor.institutionInstituto de Biomedicina do Semi-árido Brasileiro (IBISAB), Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CEeng
dc.contributor.institutionRAIMUNDO NONATO BRAGA LOBO, CNPCeng
dc.contributor.institutionCenter for Global Health, School of Medicineeng
dc.contributor.institutionCenter for Global Health, School of Medicine e Instituto de Biomedicina do Semi-árido Brasileiro (IBISAB), Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CEeng
dc.contributor.institutionCenter for Global Health, School of Medicine e Instituto de Biomedicina do Semi-árido Brasileiro (IBISAB), Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE.eng
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