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dc.contributor.authorIBELLI, A. M. G.
dc.contributor.authorNAKATA, L. C.
dc.contributor.authorANDRÉO, R.
dc.contributor.authorCOUTINHO, L. L.
dc.contributor.authorOLIVEIRA, M. C. de S.
dc.contributor.authorAMARANTE, A. F. T.
dc.contributor.authorFURLONG, J.
dc.contributor.authorZAROS, L. G.
dc.contributor.authorREGITANO, L. C. de A.
dc.date.accessioned2023-03-13T11:51:57Z-
dc.date.available2023-03-13T11:51:57Z-
dc.date.created2010-12-15
dc.date.issued2011
dc.identifier.citationVeterinary Parasitology, v. 176, n. 2-3, mar. 2011.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/870087-
dc.descriptionHaemonchus parasites are responsible for many losses in animal production. However, few studies are available, especially of zebu cattle. In this study, we investigated mRNA differences of immune response genes in naïve Nellore calves infected with Haemonchus placei, relating these differences to patterns of cellular infiltrate. Calves were infected with 15,000 H. placei L3 larvae and after 7 days lymph node and abomasum tissues were collected. IL-2, IL-4, IL-8, IL-12, IL-13, IFN-?, MCP-1, lysozyme, pepsinogen and TNF-? genes were evaluated by qPCR. Mast cells, eosinophils and globular leukocytes were counted by abomasum histology. In the infected group, IL-4, IL-13 and TNF-? were up-regulated in the abomasal lymph node. In the abomasum, IL-13 increased and TNF-? was down-regulated (p<0.05). No differences were detected for mast cells and eosinophil counts in abomasal tissue (p>0.05). We conclude that for this infection time, there was Th2 polarization but that cellular infiltrate in abomasal tissue takes longer to develop.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectMRNA profile
dc.subjectGastrointestinal parasites
dc.titlemRNA profile of Nellore calves after primary infection with Haemonchus placei.
dc.typeArtigo de periódico
dc.subject.thesagroBos Indicus
dc.subject.nalthesaurusHaemonchus placei
dc.subject.nalthesaurusNellore
dc.subject.nalthesaurusbeef cattle
dc.subject.nalthesauruscytokines
dc.format.extent2p. 195-200.eng
riaa.ainfo.id870087
riaa.ainfo.lastupdate2023-03-13
dc.identifier.doi10.1016/j.vetpar.2010.11.013
dc.contributor.institutionADRIANA M. G. IBELLI, UNIVERSIDADE FEDERAL DE SÃO CARLOS
dc.contributor.institutionL. C. NAKATA, UNIVERSIDADE FEDERAL DE SÃO CARLOSeng
dc.contributor.institutionR. ANDRÉO, UNIVERSDADE ESTADUAL PAULISTAeng
dc.contributor.institutionL. L. COUTINHO, UNIVERSIDADE DE SÃO PAULOeng
dc.contributor.institutionMARCIA CRISTINA DE SENA OLIVEIRA, CPPSEeng
dc.contributor.institutionA. F. T. AMARANTE, UNIVERSIDADE ESTADUAL DE SÃO PAULOeng
dc.contributor.institutionJOHN FURLONG, CNPGLeng
dc.contributor.institutionL. G. ZAROS, UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTEeng
dc.contributor.institutionLUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.eng
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