Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/875214
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dc.contributor.authorHIGA, R. H.pt_BR
dc.contributor.authorTOZZI, C. L.pt_BR
dc.date.accessioned2011-04-09T17:51:39Z-
dc.date.available2011-04-09T17:51:39Z-
dc.date.created2011-02-01pt_BR
dc.date.issued2009pt_BR
dc.identifier.citationGenetics and Molecular Biology, Ribeirão Preto, v. 32, n. 3, p. 626-633, 2009.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/875214pt_BR
dc.descriptionIn this work, we present a method for predicting hot spot residues by using a set of structural and evolutionary parameters. Unlike previous studies, we use a set of parameters which do not depend on the structure of the protein in complex, so that the predictor can also be used when the interface region is unknown. Despite the fact that no information concerning proteins in complex is used for prediction, the application of the method to a compiled dataset described in the literature achieved a performance of 60.4%, as measured by F-Measure, corresponding to a recall of 78.1% and a precision of 49.5%. This result is higher than those reported by previous studies using the same data set.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectEstrutura proteicapt_BR
dc.subjectInterações proteína-proteínapt_BR
dc.subjectPrevisão de resíduos hot spotspt_BR
dc.titlePrediction of binding hot spot residues by using structural and evolutionary parameters.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2011-04-10T11:11:11Zpt_BR
dc.subject.nalthesaurusProtein structurept_BR
dc.subject.nalthesaurusPredictionpt_BR
riaa.ainfo.id875214pt_BR
riaa.ainfo.lastupdate2011-02-24pt_BR
dc.contributor.institutionROBERTO HIROSHI HIGA, FEEC/UNICAMP, CNPTIA; CLÉSIO LUIS TOZZI, FEEC/UNICAMP.pt_BR
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