Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/904909
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorLEAL, L. K. A. M.pt_BR
dc.contributor.authorPIERDONÁ, T. M.pt_BR
dc.contributor.authorGÓES, J. G. S.pt_BR
dc.contributor.authorCANUTO, K. M.pt_BR
dc.contributor.authorSILVEIRA, E. R.pt_BR
dc.contributor.authorBEZERRA, A. M. E.pt_BR
dc.contributor.authorVIANA, G. S. B.pt_BR
dc.date.accessioned2011-11-04T11:11:11Zpt_BR
dc.date.accessioned2011-11-04T11:11:11Zpt_BR
dc.date.available2011-11-04T11:11:11Zpt_BR
dc.date.available2011-11-04T11:11:11Zpt_BR
dc.date.created2011-11-04pt_BR
dc.date.issued2011pt_BR
dc.identifier.citationPhytomedicine, v. 18, n. 2-3, p. 230-233, 2011.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/904909pt_BR
dc.descriptionThe objectives of this work were to carry out a comparative chemical study and to evaluate the antinociceptive and anti-inflammatory activities of ethanol extracts (EtOHE) and vanilic acid (VA) from cultivated and wild Amburana cearensis A.C. Smith (Fabaceae), an endangered species used in Northeast Brazil for the treatment of asthma. The HPLC analysis of EtOHE, showed that coumarin (CM) and VA were the major constituents from the cultivated plant, while in the extract from the wild plant the major constituents were amburoside A (AMB) and CM. Pharmacological tests were performed with male Swiss mice or male Wistar rats acutely administered with 100?400 mg/kg, p.o. of EtOHEs or 12.5?50 mg/kg, p.o. of VA. EtOHEs from A. cearensis with 4, 7 or 9 months of cultivation significantly inhibited, from 32 to 64%, both phases of the formalin test in mice. Similar results were observed with the EtOHE from the wild species. VA significantly reduced both phases of the formalin test. This effect was partially reversed by naloxone. EtOHE from cultivated or wild A. cearensis inhibited the carrageenan (Cg)-induced mice paw edema. Furthermore, VA inhibited the paw edema and the leukocyte migration in rat peritoneal cavity induced by Cg. On the other hand, it did not inhibit the edema and the increase of vascular permeability induced by dextran in the rat paw. All together, these results indicate that the EtOHE from cultivated A. cearensis exhibit similar chemical and pharmacological profiles, as related to the wild plant. VA is, at least partially, responsible for these pharmacological effects. Its antinociceptive effect occurs by a mechanism partly dependent upon the opioid system, while the anti-inflammatory action was manifested in inflammatory processes dependent on polymorphonuclear cells and are probably related to the VA inhibition of cytokines as observed by others.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectAmburana cearensispt_BR
dc.subjectHPLCpt_BR
dc.subjectAntinociceptive activitypt_BR
dc.titleA comparative chemical and pharmacological study of standardized extracts and vanillic acid from wild and cultivated Amburana cearensis A. C. Smith.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2017-05-02T11:11:11Zpt_BR
dc.subject.nalthesaurusanti-inflammatory activitypt_BR
dc.subject.nalthesaurusvanillic acidpt_BR
riaa.ainfo.id904909pt_BR
riaa.ainfo.lastupdate2017-05-02pt_BR
dc.contributor.institutionUFC; UFC; UFC; KIRLEY MARQUES CANUTO, CNPAT; UFC; UFC; UFC.pt_BR
Aparece nas coleções:Artigo em periódico indexado (CNPAT)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
AA111008.pdf292,13 kBAdobe PDFThumbnail
Visualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas

FacebookTwitterDeliciousLinkedInGoogle BookmarksMySpace