Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/939346
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dc.contributor.authorSILVA, L. F. R. Ept_BR
dc.contributor.authorMAGALHÃES, P. M. DEpt_BR
dc.contributor.authorCOSTA, M. R. F.pt_BR
dc.contributor.authorALECRIM, M. DAS G. C.pt_BR
dc.contributor.authorCHAVES, F. C. M.pt_BR
dc.contributor.authorHIDALGO, A. DE F.pt_BR
dc.contributor.authorPOHLIT, A. M.pt_BR
dc.contributor.authorVIEIRA, P. P. R.pt_BR
dc.date.accessioned2015-03-26T06:38:49Z-
dc.date.available2015-03-26T06:38:49Z-
dc.date.created2012-11-09pt_BR
dc.date.issued2012pt_BR
dc.identifier.citationMemórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 7, p. 859-866, Nov. 2012.pt_BR
dc.identifier.issn0074-0276pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/939346pt_BR
dc.descriptionArtemisinin is the active antimalarial compound obtained from the leaves of Artemisia annua L. Artemisinin, and its semi-synthetic derivatives, are the main drugs used to treat multi-drug-resistant Plasmodium falciparum (one of the human malaria parasite species). The in vitro susceptibility of P. falciparum K1 and 3d7 strains and field isolates from the state of Amazonas, Brazil, to A. annua infusions (5 g dry leaves in 1 L of boiling water) and the drug standards chloroquine, quinine and artemisinin were evaluated. The A. annua used was cultivated in three Amazon ecosystems (várzea, terra preta de índio and terra firme) and in the city of Paulínia, state of São Paulo, Brazil. Artemisinin levels in the A. annua leaves used were 0.90-1.13% (m/m). The concentration of artemisinin in the infusions was 40-46 mg/L. Field P. falciparum isolates were resistant to chloroquine and sensitive to quinine and artemisinin. The average 50% inhibition concentration values for A. annua infusions against field isolates were 0.11-0.14 μL/mL (these infusions exhibited artemisinin concentrations of 4.7-5.6 ng/mL) and were active in vitro against P. falciparum due to their artemisinin concentration. No synergistic effect was observed for artemisinin in the infusions.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectInfusionpt_BR
dc.subjectAntiplasmodialpt_BR
dc.subjectIn vitropt_BR
dc.subjectField isolatept_BR
dc.subjectAmazon Regionpt_BR
dc.titleIn vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2015-03-26T06:38:49Zpt_BR
dc.subject.thesagroArtemisia Annuaeng
riaa.ainfo.id939346pt_BR
riaa.ainfo.lastupdate2015-03-25pt_BR
dc.contributor.institutionLUIZ FRANCISCO ROCHA E SILVA, INPA, UEA, UNINORTE; PEDRO MELILLO DE MAGALHÃES, UNESP; MÔNICA REGINA FARIAS COSTA, FUNDAÇÃO DE MEDICINA TROPICAL HEITOR VIEIRA DOURADO; MARIA DAS GRAÇAS COSTA ALECRIM, FUNDAÇÃO DE MEDICINA TROPICAL HEITOR VIEIRA DOURADO; FRANCISCO CELIO MAIA CHAVES, CPAA; ARI DE FREITAS HIDALGO, UFAM; ADRIAN MARTIN POHLIT, INPA; PEDRO PAULO RIBEEIRO VIEIRA, UEA, FUNDAÇÃO DE MEDICINA TROPICAL HEITOR VIEIRA DOURADO.pt_BR
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