Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/939969
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dc.contributor.authorSOARES, J. K. B.pt_BR
dc.contributor.authorROCHA-DE-MELO, A. P.pt_BR
dc.contributor.authorMEDEIROS, M. C.pt_BR
dc.contributor.authorQUEIROGA, R. C. R. E.pt_BR
dc.contributor.authorBOMFIM, M. A. D.pt_BR
dc.contributor.authorSOUZA, A. F. O. dept_BR
dc.contributor.authorNASCIMENTO, A. L. V.pt_BR
dc.contributor.authorGUEDES, R. C. A.pt_BR
dc.date.accessioned2015-04-25T05:10:44Z-
dc.date.available2015-04-25T05:10:44Z-
dc.date.created2012-11-19pt_BR
dc.date.issued2012pt_BR
dc.identifier.citationBiochimica et Biophysica Acta (BBA) - General Subjects, v. 1820, n. 10, p. 1490-1495, Oct., 2012.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/939969pt_BR
dc.descriptionAbstract - Background: Conjugated linoleic acids (CLA) are fatty acids that are found in the lipids from goat milk, and appear to protect neurons from excitotoxicity. Methods: We investigated in developing rats the effects of a maternal CLA-rich diet (containing 7% lipids from goat milk) on body development and cerebral electrical activity of the progeny from dams receiving the CLA diet during gestation (G), lactation (L) or both periods (G + L). Results: Compared to a control group (C) receiving a diet with 7% soybean oil, body weight increased at 14, 21 and 28 days, but not at 35-45 days, in L and G + L groups (P < 0.05). No intergroup difference was found on body and brain weights, body length, abdominal and thoracic circumferences, body mass index and abdominal to thoracic circumference ratio at 35?45 days. In contrast, at this later age the CSD velocities of propagation were significantly higher (P < 0.05) in L as compared with the C and G group, and in the L + G, as compared with the C, G and L groups, suggesting a long-lasting brain effect. Conclusion: These data indicate that a maternal CLA-rich diet can differentially influence body weight increment (short-term effect), and CSD propagation (long-term effect) in the progeny, and the lactation is the most critical period for such diet actions. General significance. The facilitating effect of the lipids from goat milk on an excitability-related phenomenon in the brain (CSD) can be of clinical relevance, since CSD has been associated to neurological disturbances like migraine and epilepsy.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectBrain developmentpt_BR
dc.subjectBrain electrophysiologypt_BR
dc.subjectPhysical parameterpt_BR
dc.subjectDrug effectspt_BR
dc.subjectCortical spreading depressionpt_BR
dc.titleConjugated linoleic acid in the maternal diet differentially enhances growth and cortical spreading depression in the rat progeny.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2015-04-25T05:10:44Zpt_BR
dc.subject.thesagroCaprinopt_BR
dc.subject.thesagroLeite de cabrapt_BR
dc.subject.thesagroÁcido linoleicopt_BR
dc.subject.nalthesaurusGoat milkpt_BR
dc.subject.nalthesaurusLinoleic acidpt_BR
dc.subject.nalthesaurusPolyunsaturated fatty acidspt_BR
dc.subject.nalthesaurusRatspt_BR
riaa.ainfo.id939969pt_BR
riaa.ainfo.lastupdate2015-04-24pt_BR
dc.contributor.institutionJuliana K. B. Soares, Universidade Federal de Pernambuco (UFPE), Recife, PE; Ana P. Rocha-de-Melo, Universidade Federal de Pernambuco (UFPE), Recife, PE; Maria C. Medeiros, Universidade Federal de Pernambuco (UFPE), Recife, PE; Rita C. R. E. Queiroga, Universidade Federal da Paraíba (UFPB) - Campina Grande, PB; MARCO AURELIO DELMONDES BOMFIM, CNPC; Amanda F. O. de Souza, Universidade Federal de Pernambuco (UFPE), Recife, PE; Ana L. V. Nascimento, Universidade Federal de Pernambuco (UFPE), Recife, PE; Rubem C. A. Guedes, Universidade Federal de Pernambuco (UFPE), Recife, PE.pt_BR
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