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dc.contributor.authorCANIATO, F. F.pt_BR
dc.contributor.authorHAMBLIN, M. T.pt_BR
dc.contributor.authorGUIMARAES, C. T.pt_BR
dc.contributor.authorZHANG, Z.pt_BR
dc.contributor.authorSCHAFFERT, R. E.pt_BR
dc.contributor.authorKOCHIAN, L. V.pt_BR
dc.contributor.authorMAGALHAES, J. V.pt_BR
dc.date.accessioned2014-02-12T11:11:11Zpt_BR
dc.date.available2014-02-12T11:11:11Zpt_BR
dc.date.created2014-02-12pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationPlos One, San Francisco, v. 9, n. 1, p. 1-12, 2014.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/979541pt_BR
dc.descriptionRoot damage caused by aluminum (Al) toxicity is a major cause of grain yield reduction on acid soils, which are prevalent in tropical and subtropical regions of the world where food security is most tenuous. In sorghum, Al tolerance is conferred by SbMATE, an Al-activated root citrate efflux transporter that underlies the major Al tolerance locus, AltSB, on sorghum chromosome 3. We used association mapping to gain insights into the origin and evolution of Al tolerance in sorghum and to detect functional variants amenable to allele mining applications. Linkage disequilibrium across the AltSB locus decreased much faster than in previous reports in sorghum, and reached basal levels at approximately 1000 bp. Accordingly, intralocus recombination events were found to be extensive. SNPs and indels highly associated with Al tolerance showed a narrow frequency range, between 0.06 and 0.1, suggesting a rather recent origin of Al tolerance mutations within AltSB.A haplotype network analysis suggested a single geographic and racial origin of causative mutations in primordial guinea domesticates in West Africa. Al tolerance assessment in accessions harboring recombinant haplotypes suggests that causative polymorphisms are localized to a, 6 kb region including intronic polymorphisms and a transposon (MITE) insertion, whose size variation has been shown to be positively correlated with Al tolerance. The SNP with the strongest association signal, located in the second SbMATE intron, recovers 9 of the 14 highly Al tolerant accessions and 80% of all the Al tolerant and intermediately tolerant accessions in the association panel. Our results also demonstrate the pivotal importance of knowledge on the origin and evolution of Al tolerance mutations in molecular breeding applications. Allele mining strategies based on associated loci are expected to lead to the efficient identification, in diverse sorghum germplasm, of Al tolerant accessions able maintain grain yields under Al toxicity.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleAssociation mapping provides insights into the origin and the fine structure of the sorghum aluminum tolerance locus, AltSB.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2017-05-24T11:11:11Zpt_BR
dc.subject.thesagroSorgopt_BR
dc.subject.thesagroAlumíniopt_BR
dc.subject.thesagroToxidezpt_BR
dc.subject.thesagroMelhoramento genético vegetalpt_BR
dc.subject.thesagroSorghum bicolorpt_BR
dc.subject.nalthesaurusPlant breedingpt_BR
dc.subject.nalthesaurusToxicitypt_BR
riaa.ainfo.id979541pt_BR
riaa.ainfo.lastupdate2017-05-24pt_BR
dc.identifier.doi10.1371/journal.pone.0087438pt_BR
dc.contributor.institutionCLAUDIA TEIXEIRA GUIMARAES, CNPMS; ROBERT EUGENE SCHAFFERT, CNPMS; JURANDIR VIEIRA DE MAGALHAES, CNPMS.pt_BR
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