Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/984641
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dc.contributor.authorBUZANSKAS, M. E.
dc.contributor.authorGROSSI, D. A.
dc.contributor.authorVENTURA, R. V.
dc.contributor.authorSCHENKEL, F. S.
dc.contributor.authorSARGOLZAEI, M.
dc.contributor.authorMEIRELLES, S. L. C.
dc.contributor.authorMOKRY, F. B.
dc.contributor.authorHIGA, R. H.
dc.contributor.authorMUDADU, M. de A.
dc.contributor.authorSILVA, M. V. G. B.
dc.contributor.authorNICIURA, S. C. M.
dc.contributor.authorTORRES JUNIOR, R. A. de A.
dc.contributor.authorALENCAR, M. M. de
dc.contributor.authorREGITANO, L. C. de A.
dc.contributor.authorMUNARI, D. P.
dc.date.accessioned2018-05-17T00:42:42Z-
dc.date.available2018-05-17T00:42:42Z-
dc.date.created2014-04-15
dc.date.issued2014
dc.identifier.citationPlos One, v. 9, n. 4, e94802, 2014.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/984641-
dc.descriptionStudies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and K Canchim + K Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate regions for body weight traits were detected and some of them have interesting biological functions, of which most have not been previously reported. The observation of QTL reports for body weight traits, covering areas surrounding the genes (SNPs) herein identified provides more evidence for these associations. Future studies targeting these areas could provide further knowledge to uncover the genetic architecture underlying growth traits in Canchim cattle.eng
dc.language.isoengpt_BR
dc.rightsopenAccesspt_BR
dc.subjectGenome-wide
dc.subjectGrowth trait
dc.subjectRace Canchim
dc.subjectRaça Canchim
dc.titleGenome-wide association for growth traits in Canchim beef cattle.
dc.typeArtigo de periódico
dc.date.updated2018-05-17T00:42:42Zpt_BR
dc.subject.thesagroGado de corte
dc.format.extent28 p.eng
riaa.ainfo.id984641
riaa.ainfo.lastupdate2018-05-16
dc.identifier.doi10.1371/journal.pone.0094802eng
dc.contributor.institutionMARCOS E. BUZANSKAS, Universidade Estadual Paulista
dc.contributor.institutionDANIELA A. GROSSI, University of Guelpheng
dc.contributor.institutionRICARDO V. VENTURA, University of Guelpheng
dc.contributor.institutionFLAVIO S. SCHENKEL, University of Guelpheng
dc.contributor.institutionMEHDI SARGOLZAEI, University of Guelpheng
dc.contributor.institutionSARAH L. C. MEIRELLES, Federal University of Lavraseng
dc.contributor.institutionFABIANA B. MOKRY, Federal University of São Carloseng
dc.contributor.institutionROBERTO HIROSHI HIGA, CNPTIAeng
dc.contributor.institutionMAURICIO DE ALVARENGA MUDADU, CPPSEeng
dc.contributor.institutionMARCOS VINICIUS GUALBERTO B SILVA, CNPGLeng
dc.contributor.institutionSIMONE CRISTINA MEO NICIURA, CPPSEeng
dc.contributor.institutionROBERTO AUGUSTO DE A TORRES JUNIOR, CNPGCeng
dc.contributor.institutionMAURICIO MELLO DE ALENCAR, CPPSEeng
dc.contributor.institutionLUCIANA CORREIA DE ALMEIDA REGITANO, CPPSEeng
dc.contributor.institutionDANÍSIO P. MUNARI, Universidade Estadual Paulista.eng
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