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dc.contributor.authorCAETANO, L. C.pt_BR
dc.contributor.authorGENNARO, F. G. O.pt_BR
dc.contributor.authorCOELHO, K.pt_BR
dc.contributor.authorARAÚJO, F. M.pt_BR
dc.contributor.authorVILA, R. A.pt_BR
dc.contributor.authorARAÚJO, A.pt_BR
dc.contributor.authorBERNARDO, A. de M.pt_BR
dc.contributor.authorMARCONDES, C. R.pt_BR
dc.contributor.authorLOPES, S. M. C. de S.pt_BR
dc.contributor.authorRAMOS, E. S.pt_BR
dc.date.accessioned2014-04-24T11:11:11Zpt_BR
dc.date.available2014-04-24T11:11:11Zpt_BR
dc.date.created2014-04-24pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationGenetics and Molecular Research, v. 13, n. 1, p. 838-849, 2014.pt_BR
dc.identifier.issn1656-5680pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/985036pt_BR
dc.descriptionThe chicken (Gallus gallus) embryo has been used as a classic model system for developmental studies because of its easy accessibility for surgical manipulation during embryonic development. Sex determination in birds is chromosomally based (ZZ for males and ZW for females); however, the basic mechanism of sex determination is still unknown. Here, the dynamics of expression of candidate genes implicated in vertebrate sex determination and differentiation were studied during embryonic chicken gonadal development. Gene expression profiles were obtained before, during, and after gonadal sex differentiation in females and males for DMRT1, SOX3, SOX9, DAX MHM and sex-determining gene expression in chicken embryos SCII, HINTZ, HINTW, and the male hypermethylated (MHM) region. Transcripts for the HINTZ, DMRT1, DAX1, SCII, and SOX9 genes were observed in both sexes, but expression was higher in male gonads and may be correlated with testicular differentiation. The expression patterns of HINTW, SOX3, and MHM suggest that they may act in ovary development and may be involved in meiosis entry. MHM was upregulated and DMRT1 was downregulated in females at the same developmental stage. This may indicate a regulation of DMRT1 by MHM ncRNA. Similar dynamics were observed between HINTW and HINTZ . This study reports on the MHM expression profile during gonadal development and its correlation with the expression of genes involved in vertebrate sex determination.pt_BR
dc.language.isoengpt_BR
dc.rightsopenAccesspt_BR
dc.subjectGonadpt_BR
dc.subjectDevelopmentpt_BR
dc.subjectChickenpt_BR
dc.subjectDosage compensationpt_BR
dc.titleDifferential expression of the MHM region and of sex-determining-related genes during gonadal development in chicken embryos.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2015-10-22T11:11:11Zpt_BR
dc.subject.nalthesaurusepigeneticspt_BR
riaa.ainfo.id985036pt_BR
riaa.ainfo.lastupdate2015-10-22pt_BR
dc.identifier.doi10.4238/2014.February.13.2eng
dc.contributor.institutionL. C. CAETANO, Universidade de São Paulopt_BR
dc.contributor.institutionF. G. O. GENNARO, Universidade de São Pauloeng
dc.contributor.institutionK. COELHO, Universidade de São Pauloeng
dc.contributor.institutionF. M. ARAÚJO, Universidade de São Pauloeng
dc.contributor.institutionR. A. VILA, Universidade de São Pauloeng
dc.contributor.institutionA. ARAÚJO, Universidade de São Pauloeng
dc.contributor.institutionA. DE MELO BERNARDO, Leiden University Medical Centereng
dc.contributor.institutionCINTIA RIGHETTI MARCONDES, CPPSEeng
dc.contributor.institutionS. M. CHUVA DE SOUSA LOPES, Leiden University Medical Centereng
dc.contributor.institutionE. S. RAMOS, Universidade de São Paulo.eng
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