Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/986150
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorBUZANSKAS, M. E.pt_BR
dc.contributor.authorGROSSI, D. A.pt_BR
dc.contributor.authorVENTURA, R. V.pt_BR
dc.contributor.authorSCHENKEL, F. S.pt_BR
dc.contributor.authorSARGOLZAEI, M.pt_BR
dc.contributor.authorMEIRELLES, S. L. C. Opt_BR
dc.contributor.authorMOKRY, F. B.pt_BR
dc.contributor.authorHIGA, R. H.pt_BR
dc.contributor.authorMUDADU, M. de A.pt_BR
dc.contributor.authorSILVA, M. V. G. B.pt_BR
dc.contributor.authorNICIURA, S. C. M.pt_BR
dc.contributor.authorTORRES JUNIOR, R. A. de A.pt_BR
dc.contributor.authorALENCAR, M. M. dept_BR
dc.contributor.authorREGITANO, L. C. de A.pt_BR
dc.contributor.authorMUNARI, D. P.pt_BR
dc.date.accessioned2014-07-26T06:55:48Z-
dc.date.available2014-07-26T06:55:48Z-
dc.date.created2014-05-14pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationPlos One, v. 9, n. 4, e94802 2014.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/986150pt_BR
dc.descriptionStudies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and ½ Canchim + ½ Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate regions for body weight traits were detected and some of them have interesting biological functions, of which most have not been previously reported. The observation of QTL reports for body weight traits, covering areas surrounding the genes (SNPs) herein identified provides more evidence for these associations. Future studies targeting these areas could provide further knowledge to uncover the genetic architecture underlying growth traits in Canchim cattle.eng
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectGenome-widept_BR
dc.subjectGrowth traitpt_BR
dc.subjectRace Canchimpt_BR
dc.subjectRaça Canchimpt_BR
dc.titleGenome-wide association for growth traits in Canchim beef cattle.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2014-07-26T06:55:48Zpt_BR
dc.subject.thesagroGado de cortept_BR
riaa.ainfo.id986150pt_BR
riaa.ainfo.lastupdate2014-07-25pt_BR
dc.contributor.institutionMARCOS VINICIUS GUALBERTO B SILVA, CNPGL.pt_BR
Aparece nas coleções:Artigo em periódico indexado (CNPGL)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ArtigoMViniciusjournal.plosone.0094802.pdf765.87 kBAdobe PDFThumbnail
Visualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas

FacebookTwitterDeliciousLinkedInGoogle BookmarksMySpace