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dc.contributor.authorUTSUNOMIYA, Y. T.pt_BR
dc.contributor.authorCARMO, A. S.pt_BR
dc.contributor.authorNEVES, H. H. R.pt_BR
dc.contributor.authorCARVALHEIRO, R.pt_BR
dc.contributor.authorMATOS, M. C.pt_BR
dc.contributor.authorZAVAREZ, L. B.pt_BR
dc.contributor.authorITO, P. K. R. K.pt_BR
dc.contributor.authorO'BRIEN, A. M. P.pt_BR
dc.contributor.authorSOLKNER, J.pt_BR
dc.contributor.authorPORTO-NETO, L. R.pt_BR
dc.contributor.authorSCHENKEL, F. S.pt_BR
dc.contributor.authorMcEWAN, J.pt_BR
dc.contributor.authorCOLE, J. B.pt_BR
dc.contributor.authorSILVA, M. V. G. B.pt_BR
dc.contributor.authorVAN TASSELL, C. P.pt_BR
dc.contributor.authorSONSTEGARD, T. S.pt_BR
dc.contributor.authorGARCIA, J. F.pt_BR
dc.date.accessioned2014-07-26T06:55:52Z-
dc.date.available2014-07-26T06:55:52Z-
dc.date.created2014-05-19pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationPlos One v. 9, n. 2, p. 1-9, 2014.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/986515pt_BR
dc.descriptionThe reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC can contribute to the identification of diagnostic markers for reproductive performance and uncover molecular mechanisms underlying complex aspects of bovine reproductive biology. In this paper, we report a genome-wide scan for chromosome segments explaining differences in SC, using data of 861 Nellore bulls (Bos indicus) genotyped for over 777,000 single nucleotide polymorphisms. Loci that excel from the genome background were identified on chromosomes 4, 6, 7, 10, 14, 18 and 21. The majority of these regions were previously found to be associated with reproductive and body size traits in cattle. The signal on chromosome 14 replicates the pleiotropic quantitative trait locus encompassing PLAG1 that affects male fertility in cattle and stature in several species. Based on intensive literature mining, SP4, MAGEL2, SH3RF2, PDE5A and SNAI2 are proposed as novel candidate genes for SC, as they affect growth and testicular size in other animal models. These findings contribute to linking reproductive phenotypes to gene functions, and may offer new insights on the molecular biology of male fertility.eng
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectGenome-widept_BR
dc.subjectRace Nellorept_BR
dc.subjectRaça Canchimpt_BR
dc.titleGenome-wide mapping of loci explaining variance in scrotal circumference in Nellore Cattle.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2014-07-26T06:55:52Zpt_BR
dc.subject.thesagroGado de cortept_BR
riaa.ainfo.id986515pt_BR
riaa.ainfo.lastupdate2014-07-25pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0088561eng
dc.contributor.institutionYURI T. UTSUNOMIYA, UNESPpt_BR
dc.contributor.institutionADRIANA S. CARMO, UNESPeng
dc.contributor.institutionHAROLDO H. R. NEVES, UNESPeng
dc.contributor.institutionROBERTO CARVALHEIRO, UNESPeng
dc.contributor.institutionGenSyseng
dc.contributor.institutionMARCIA C. MATOS, UNESPeng
dc.contributor.institutionLUDMILLA B. ZAVAREZ, UNESPeng
dc.contributor.institutionPIER K. R. K. ITO, UNESPeng
dc.contributor.institutionANA M. PEREZ O'BRIEN, University of Natural Resources and Life Sciences, Vienna, Austriaeng
dc.contributor.institutionJOHANN SOLKNER, University of Natural Resources and Life Sciences, Vienna, Austriaeng
dc.contributor.institutionLAERCIO R. PORTO-NETO, CSIRO, Queenslandeng
dc.contributor.institutionFLAVIO S. SCHENKEL, University of Guelph, Guelph, Ontarioeng
dc.contributor.institutionJOHN McEWAN, AgResearch, Invermay, Mosgiel, Otago, New Zealandeng
dc.contributor.institutionJOHN B. COLE, ARS-USDAeng
dc.contributor.institutionMARCOS VINICIUS GUALBERTO B SILVA, CNPGLeng
dc.contributor.institutionCURTIS P. VAN TASSELL, ARS-USDAeng
dc.contributor.institutionTAD S. SONSTEGARD, ARS-USDAeng
dc.contributor.institutionJOSE FERNANDO GARCIA, UNESP.eng
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