Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/996875
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dc.contributor.authorGASPAROTTO, J.pt_BR
dc.contributor.authorSOMENSI, N.pt_BR
dc.contributor.authorBORTOLIN, R. C.pt_BR
dc.contributor.authorGIRARDI, C. S.pt_BR
dc.contributor.authorKUNZLER, A.pt_BR
dc.contributor.authorRABELO, T. K.pt_BR
dc.contributor.authorSCHNORR, C. E.pt_BR
dc.contributor.authorMORESCO, K. Z.pt_BR
dc.contributor.authorBASSANI, V. L.pt_BR
dc.contributor.authorYATSU, F. K. J.pt_BR
dc.contributor.authorVIZZOTTO, M.pt_BR
dc.contributor.authorRASEIRA, M. do C. B.pt_BR
dc.contributor.authorZANOTTO-FILHO, A.pt_BR
dc.contributor.authorMOREIRA, J. C. F.pt_BR
dc.contributor.authorGELAIN, D. P.pt_BR
dc.date.accessioned2014-10-08T11:11:11Zpt_BR
dc.date.available2014-10-08T11:11:11Zpt_BR
dc.date.created2014-10-08pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationThe Journal of Nutritional Biochemistry, v. 25, n. 12, p. 1282?1295, Dec. 2014.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/996875pt_BR
dc.descriptionThe present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl4) in rats. Tissue damage (carbonyl, thiobarbituric acid reactive species and sulfhydril), antioxidant enzymes activity (catalase and superoxide dismutase) and inflammatory parameters [tumor necrosis factor (TNF)-? and interleukin (IL)-1? levels, and receptor for advanced glycation end-products (RAGE) and nuclear factor (NF)?B-p65 immunocontent] were investigated. Our findings demonstrated that Peel, PPP and FPP (200 or 400 mg/kg) daily administration by oral gavage for 30 days conferred a significant protection against CCl4-induced antioxidant enzymes activation and, most importantly, oxidative damage to lipids and proteins as well as blocked induction of inflammatory mediators such as TNF-?, IL-1?, RAGE and NF?B. This antioxidant/anti-inflammatory effect seems to be associated with the abundance of carotenoids and polyphenols present in peach-derived products, which are enriched in fresh-fruit-derived preparations (Peel and FPP) but are also present in PPP. The Syrup — which was the least enriched in antioxidants — displayed no protective effect in our experiments. These effects cumulated in decreased levels of transaminases and lactate dehydrogenase leakage into serum and maintenance of organ architecture. Therefore, the herein presented results show evidence that supplementation with peach products may be protective against organ damage caused by oxidative stress, being interesting candidates for production of antioxidant-enriched functional foods.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectPeachpt_BR
dc.subjectNF?B-p65pt_BR
dc.subjectRAGEpt_BR
dc.subjectAntioxidantpt_BR
dc.subjectAnti-inflammatorypt_BR
dc.titlePreventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2015-03-06T11:11:11Zpt_BR
dc.subject.nalthesauruscarbon tetrachloridept_BR
riaa.ainfo.id996875pt_BR
riaa.ainfo.lastupdate2015-03-06pt_BR
dc.identifier.doidoi:10.1016/j.jnutbio.2014.07.004pt_BR
dc.contributor.institutionJuciano Gasparotto, UFRGS; Nauana Somensi; Rafael Calixto Bortolin; Carolina Saibro Girardi; Alice Kunzler; Thallita Kelly Rabelo; Carlos Eduardo Schnorr; Karla Suzana Moresco; Valquiria Linck Bassani; Francini Kiyono Jorge Yatsu; MARCIA VIZZOTTO, CPACT; MARIA DO CARMO BASSOLS RASEIRA, CPACT; Alfeu Zanotto-Filho; José Claudio Fonseca Moreira; Daniel Pens Gelain.pt_BR
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