Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1006604
Unidade da Embrapa/Coleção:: Embrapa Gado de Leite - Artigo em periódico indexado (ALICE)
Data do documento: 24-Jan-2015
Tipo do Material: Artigo em periódico indexado (ALICE)
Autoria: MOKRY, F. B.
BUZANSKAS, M. E.
MUDADU, M. de A.
GROSSI, D. do A.
HIGA, R. H.
VENTURA, R. V.
LIMA, A. O. de
SARGOLZAEI, M.
MEIRELLES, S. L. C.
SCHENKEL, F. S.
SILVA, M. V. G. B.
NICIURA, S. C. M.
ALENCAR, M. M. de
MINARI, D. P.
REGITANO, L. C. de A.
Informaçães Adicionais: MARCOS VINICIUS GUALBERTO B SILVA, CNPGL.
Título: Linkage disequilibrium and haplotype block structure in a composite beef cattle breed.
Edição: 2014
Fonte/Imprenta: BMC Genomics, London v. 15, p. 1-9, Oct. 2014.
Idioma: en
Notas: Suppl 7.
Palavras-chave: Composite
Desequilíbrio de ligação
Genome wide association studies
Halplotype block
Linjage disequilibirium
Polimorfismo de nucleotídeo único.
Conteúdo: Abstract. Background: The development of linkage disequilibrium (LD) maps and the characterization of haplotype block structure at the population level are useful parameters for guiding genome wide association (GWA) studies, and for understanding the nature of non-linear association between phenotypes and genes. The elucidation of haplotype block structure can reduce the information of several single nucleotide polymorphisms (SNP) into the information of a haplotype block, reducing the number of SNPs in a coherent way for consideration in GWA and genomic selection studies. Results: The maximum average LD, measured by r2 varied between 0.33 to 0.40 at a distance of < 2.5 kb, and the minimum average values of r2 varied between 0.05 to 0.07 at distances ranging from 400 to 500 kb, clearly showing that the average r2 reduced with the increase in SNP pair distances. The persistence of LD phase showed higher values at shorter genomic distances, decreasing with the increase in physical distance, varying from 0.96 at a distance of < 2.5 kb to 0.66 at a distance from 400 to 500 kb. A total of 78% of all SNPs were clustered into haplotype blocks, covering 1,57 Mb of the total autosomal genome size. Conclusions: This study presented the first high density linkage disequilibrium map and haplotype block structure for a composite beef cattle population, and indicates that the high density SNP panel over 700 k can be used for genomic selection implementation and GWA studies for Canchim beef cattle.
Thesagro: Gado de corte.
NAL Thesaurus: beef cattle
linkage disequilibrium
single nucleotide polymorphism.
Ano de Publicação: 2014
Aparece nas coleções:Artigo em periódico indexado (CNPGL)

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