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|Title:||Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract.|
|Authors:||SILVA, D. T. da|
SMANIOTTO, F. A.
COSTA, I. F.
MONTEIRO, C. S.
BARCIA, M. T.
|Affiliation:||DARIANE TRIVISIOL DA SILVA; FRANCIELE ALINE SMANIOTTO; ISABELLA FERREIRA COSTA; JULIA BARANZELLI; ALINE MULLER; SABRINA SOMACAL; CAMILA SANT'ANNA MONTEIRO; MARCIA VIZZOTTO, CPACT; ELISEU RODRIGUES; MILENE TEIXEIRA BARCIA; TATIANA EMANUELLI.|
|Citation:||Food Chemistry, v. 364, 130370, Dec. 2021.|
|Description:||This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins.|
|Type of Material:||Artigo de periódico|
|Appears in Collections:||Artigo em periódico indexado (CPACT)|
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