Title:	Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract.
Authors:	SILVA, D. T. da SMANIOTTO, F. A. COSTA, I. F. BARANZELLI, J. MULLER, A. SOMACAL, S. MONTEIRO, C. S. VIZZOTTO, M. RODRIGUES, E. BARCIA, M. T. EMANUELLI, T.
Affiliation:	DARIANE TRIVISIOL DA SILVA; FRANCIELE ALINE SMANIOTTO; ISABELLA FERREIRA COSTA; JULIA BARANZELLI; ALINE MULLER; SABRINA SOMACAL; CAMILA SANT'ANNA MONTEIRO; MARCIA VIZZOTTO, CPACT; ELISEU RODRIGUES; MILENE TEIXEIRA BARCIA; TATIANA EMANUELLI.
Date Issued:	2021
Citation:	Food Chemistry, v. 364, 130370, Dec. 2021.
Description:	This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins.
Thesagro:	Mirtilo Extrato
Keywords:	Composto
DOI:	doi.org/10.1016/j.foodchem.2021.130370
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPACT)