Title:	Red sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial design: cytotoxicity and cellular reactive oxygen species levels.
Authors:	CHURA, S. S. D. MEMÓRIA, K. A. S. LOPES, A. T. PELISSARI, F. M. SILVEIRA, J. V. W. da BEZERRA, J. de A. CHAVES, F. C. M. RODRIGUES, A. P. FARIA, J. A. Q. A. CARNEIRO, G.
Affiliation:	SOFIA SANTOS DONAIRE CHURA, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; KATHELEN ANNE SUDO MEMÓRIA, UNIVERSIDADE FEDERAL DO AMAZONAS; AMANDA TIBÃES LOPES, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; FRANCIELE MARIA PELISSARI, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JOÃO VINÍCIOS WIRBITZKI DA SILVEIRA, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JAQUELINE DE ARAÚJO BEZERRA, FEDERAL INSTITUTE OF EDUCATION, SCIENCE AND TECHNOLOGY OF AMAZONAS; FRANCISCO CELIO MAIA CHAVES, CPAA; ANA PAULA RODRIGUES, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JERUSA ARAÚJO QUINTÃO ARANTES FARIA, UNIVERSIDADE FEDERAL DO AMAZONAS; GUILHERME CARNEIRO, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS.
Date Issued:	2023
Citation:	Frontiers in Pharmacology, v. 14, art. 1176629, 2023.
Description:	Amazonian flora includes several species with the potential to develop pharmaceutical and biotechnological products. The essential oils from Amazonian species possess some biological properties, such as antioxidant, antibacterial, and cytotoxic activities. The essential oil of red sacaca (RSO), Croton cajucara Benth., contains metabolites characterized by antioxidant and anti-inflammatory activities. Nanostructured lipid carriers (NLC) are an advantageous alternative for the effective delivery of drugs because they can solubilize lipophilic actives and reduce their cytotoxicity. This study aimed to optimize the synthesis of RSO-loaded nanostructured lipid carriers (NLC-RSO) using a 23 factorial design and investigate their antioxidant and cytotoxic effects. The red sacaca essential oil (RSO) metabolite profile was characterized using gas chromatography coupled with a mass spectrometer (GC-MS), identifying 33 metabolites, with linalool and 7-hydroxy-calamenene as the major ones, as reported in the literature.
NAL Thesaurus:	Croton cajucara Nanotechnology
Keywords:	Amazon plants Rotational central composite design Nanotecnologia Plant metabolites Sacaca
DOI:	https://doi.org/10.3389/fphar.2023.1176629
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPAA)