Title:	Capra hircus outliers markers in Brazil: searching for genomic regions under the action of natural selection.
Authors:	DINIZ SOBRINHO, F. de A. MOURA, J. de O. BAJAY, M. M. CASTELO BRANCO, L. BEZERRA, R. D. S. ARAÚJO, A. M. de
Affiliation:	FRANCISCO DE A. DINIZ SOBRINHO, UNIVERSIDADE FEDERAL DO PIAUÍ, Teresina-PI; JEANE DE O. MOURA, INSTITUTO FEDERAL DO PIAUÍ, Teresina-PI; MIKLOS M. BAJAY, UNIVERSIDADE DO ESTADO DE SANTA CATARINA, Laguna-SC; LEONARDO CASTELO BRANCO, UNIVERSIDADE FEDERAL RURAL DA AMAZÔNIA, Belém-PA; ROOSEVELT D. S. BEZERRA, INSTITUTO FEDERAL DO PIAUÍ, Teresina-PI; ADRIANA MELLO DE ARAUJO, CPAP.
Date Issued:	2023
Citation:	Genetics and Molecular Biology, v. 46, n. 3, e20230084, 2023.
Description:	Identifying genome regions subject to selection in local breeds of Brazil is an opportunity to elucidate the C. hircus genome plasticity, flowing the colonization history of the country. Using SNP Bead Chip Illumina 50K genotyping of Brazilian Anglo-Nubian (standardized breed) and Marota (local endangered population from the semiarid area of Brazil) to show outliers loci in genome regions subject to selection. After applying data quality control, 45,600 SNPs were included in this investigation. Principal component analysis (PCAdapt) and FDIST2 analysis signalized 14 genomic regions more affected by selection in the Brazilian dry zone environment. The genome study signalized regions that are close to the sequences of genes related to growth and embryonic skeletal development (FGF12, AMPD2, OSTN). In addition, flagged regions close to the genes UTSB2 and SLC5A2 contribute to research on functional adaptation with low water needs and poor nutritive diet to survive. Both genes encode proteins that act on osmotic pathways and avoid cell flooding on stress cell responses. Further studies on the genetic role and involvement of these outliers? genomic regions, building a robust conceptual high-resolution map of natural selection drives, help to achieve hardiness candidate genes linked to the evolutionary history of Capra hircus in the semiarid area of Brazil.
Thesagro:	Caprino Capra Hircus Seleção Genoma
NAL Thesaurus:	Genome Natural selection
Keywords:	Candidate genes Hardiness Outliers Non-neutral loci Tropical adaptation Seleção natural
ISSN:	1678-4685
DOI:	https://doi.org/10.1590/1678-4685-GMB-2023-0084
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPAP)