Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1026401
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dc.contributor.authorJESUS, D. R.pt_BR
dc.contributor.authorBARBOSA, L. N.pt_BR
dc.contributor.authorPRANDO, T. B. L.pt_BR
dc.contributor.authorMARTINS, L. F.pt_BR
dc.contributor.authorGASPAROTTO, F.pt_BR
dc.contributor.authorGUEDES, K. M. R.pt_BR
dc.contributor.authorDRAGUNSKI, D. C.pt_BR
dc.contributor.authorLOURENÇO, E. L. B.pt_BR
dc.contributor.authorDALSENTER, P. R.pt_BR
dc.contributor.authorGASPAROTTO JUNIOR, A.pt_BR
dc.date.accessioned2017-04-16T11:59:40Z-
dc.date.available2017-04-16T11:59:40Z-
dc.date.created2015-10-14pt_BR
dc.date.issued2015pt_BR
dc.identifier.citationEvidence-Based Complementary and Alternative Medicine, 2015.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1026401pt_BR
dc.descriptionThe large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity inWistar rats, indicating possible safety of this biofilm.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectBiodegradable filmspt_BR
dc.subjectFCSApt_BR
dc.subjectDegradable productspt_BR
dc.titleNinety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2017-04-16T11:59:40Zpt_BR
dc.subject.thesagroTóxicopt_BR
dc.subject.thesagroMandiocapt_BR
dc.subject.thesagroManihot Esculentapt_BR
dc.subject.nalthesaurusBiodegradationpt_BR
riaa.ainfo.id1026401pt_BR
riaa.ainfo.lastupdate2015-12-03pt_BR
dc.identifier.doi10.1155/2015/390416pt_BR
dc.contributor.institutionDOUGLAS ROSSI JESUS, UNIPAR - Universidade Paranaense; LORENA NERIS BARBOSA, UFPR; THIAGO BRUNO LIMA PRANDO, UNIPAR; LEONARDO FRANCO MARTINS, UNIPAR; FRANCIELLI GASPAROTTO, CESUMAR; KARLA MORAES ROCHA GUEDES, CPAP; DOUGLAS CARDOSO DRAGUNSKI, UNIPAR; EMERSON LUIZ BOTELHO LOURENÇO, UNIPAR; PAULO ROBERTO DALSENTER, UFPR; ARQUIMEDES GASPAROTTO JUNIOR, UFGD.pt_BR
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