Título:	Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
Autor:	JESUS, D. R. BARBOSA, L. N. PRANDO, T. B. L. MARTINS, L. F. GASPAROTTO, F. GUEDES, K. M. R. DRAGUNSKI, D. C. LOURENÇO, E. L. B. DALSENTER, P. R. GASPAROTTO JUNIOR, A.
Afiliación:	DOUGLAS ROSSI JESUS, UNIPAR - Universidade Paranaense; LORENA NERIS BARBOSA, UFPR; THIAGO BRUNO LIMA PRANDO, UNIPAR; LEONARDO FRANCO MARTINS, UNIPAR; FRANCIELLI GASPAROTTO, CESUMAR; KARLA MORAES ROCHA GUEDES, CPAP; DOUGLAS CARDOSO DRAGUNSKI, UNIPAR; EMERSON LUIZ BOTELHO LOURENÇO, UNIPAR; PAULO ROBERTO DALSENTER, UFPR; ARQUIMEDES GASPAROTTO JUNIOR, UFGD.
Año:	2015
Referencia:	Evidence-Based Complementary and Alternative Medicine, 2015.
Descripción:	The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity inWistar rats, indicating possible safety of this biofilm.
Thesagro:	Tóxico Mandioca Manihot Esculenta
NAL Thesaurus:	Biodegradation
Palabras clave:	Biodegradable films FCSA Degradable products
DOI:	10.1155/2015/390416
Tipo de Material:	Artigo de periódico
Acceso:	openAccess
Aparece en las colecciones:	Artigo em periódico indexado (CPAP)