Título:	In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.
Autoria:	LIMA, R. B. S. SILVA, L. F. R. e MELO, M. R. S. COSTA, J. S. PICANÇO, N. S. LIMA, E. S. VASCONCELLOS, M. C. BOLETI, A. P. A. SANTOS, J. M. P. AMORIM, R. C. N. CHAVES, F. C. M. COUTINHO, J. P. TADEI, W. P. KRETTLI, A. U. POHLIT, A. M.
Afiliação:	Renata B. S. Lima; Luiz F. Rocha e Silva; Marcia R. S. Melo; Jaqueline S. Costa; Neila S. Picanço; Emerson S. Lima; Marne C. Vasconcellos; Ana Paula A. Boleti; Jakeline M. P. Santos; Rodrigo C. N. Amorim; FRANCISCO CELIO MAIA CHAVES, CPAA; Julia P. Coutinho; Wanderli P. Tadei, INPA; Antoniana U. Krettli; Adrian M. Pohlit.
Ano de publicação:	2015
Referência:	Malaria Journal, v. 14, p. 1-14, Dec. 2015.
Conteúdo:	The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-resistance is of concern. There is an urgent need for new anti-malarials. Traditionally used Amazonian plants may provide new treatments for drug-resistant P. vivax and P. falciparum. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated.
Thesagro:	Anacardium Occidentale Paullinia Cupana
NAL Thesaurus:	Croton cajucara Plasmodium berghei Plasmodium falciparum malaria
Palavras-chave:	Antiplasmodial Cytotoxic Andropogon leucostachyus Xylopia amazonica Zanthoxylum djalma-batistae
Digital Object Identifier:	doi:10.1186/s12936-015-0999-2
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CPAA)