Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1037631
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dc.contributor.authorSILVA, A. P. C.pt_BR
dc.contributor.authorMACÊDO, A. A.pt_BR
dc.contributor.authorCOSTA, L. F.pt_BR
dc.contributor.authorROCHA, C. E.pt_BR
dc.contributor.authorGARCIA, L. N. N.pt_BR
dc.contributor.authorFARIAS, J. R. D.pt_BR
dc.contributor.authorGOMES, P. P. R.pt_BR
dc.contributor.authorTEIXEIRA, G. C.pt_BR
dc.contributor.authorFONSECA, K. W. J.pt_BR
dc.contributor.authorMAIA, A. R. F.pt_BR
dc.contributor.authorNEVES, G. G.pt_BR
dc.contributor.authorROMÃO, E. L.pt_BR
dc.contributor.authorSILVA, T. M. A.pt_BR
dc.contributor.authorMOL, J. P. S.pt_BR
dc.contributor.authorOLIVEIRA, R. M.pt_BR
dc.contributor.authorARAÚJO, M. S. S.pt_BR
dc.contributor.authorNASCIMENTO, E. F.pt_BR
dc.contributor.authorMARTINS-FILHO, O. A.pt_BR
dc.contributor.authorBRANDAO, H. de M.pt_BR
dc.contributor.authorPAIXÃO, T. A.pt_BR
dc.contributor.authorSANTOS, R. L.pt_BR
dc.date.accessioned2016-02-18T11:11:11Zpt_BR
dc.date.available2016-02-18T11:11:11Zpt_BR
dc.date.created2016-02-18pt_BR
dc.date.issued2015pt_BR
dc.identifier.citationPlos One, v. 10, n. 8, e013865, 2015.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1037631pt_BR
dc.descriptionThis study aimed to evaluate protection induced by the vaccine candidate B. ovis ΔabcBA against experimental challenge with wild type B. ovis in rams. Rams were subcutaneously immunized with B. ovis ΔabcBA encapsulated with sterile alginate or with the non encapsulated vaccine strain. Serum, urine, and semen samples were collected during two months after immunization. The rams were then challenged with wild type B. ovis (ATCC25840), and the results were compared to non immunized and experimentally challenged rams. Immunization, particularly with encapsulated B. ovis ΔabcBA, prevented infection, secretion of wild type B. ovis in the semen and urine, shedding of neutrophils in the semen, and the development of clinical changes, gross and microscopic lesions induced by the wild type B. ovis reference strain. Collectively, our data indicates that the B. ovis ΔabcBA strain is an exceptionally good vaccine strain for preventing brucellosis caused by B. ovis infection in rams.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleEncapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (delta-abcBA) Protects against Wild Type Brucella ovis in Rams.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2016-02-19T11:11:11Zpt_BR
dc.subject.nalthesaurusanimal healthpt_BR
riaa.ainfo.id1037631pt_BR
riaa.ainfo.lastupdate2016-02-19pt_BR
dc.contributor.institutionAna P. C. SILVA, UFMG; Auricélio A. Macêdo, UFMG; Luciana F. Costa, UFMG; Cláudia E. Rocha, UFMG; Luize N. N. Garcia, UFMG; Jade R. D. Farias, UFMG; Priscilla P. R. Gomes, UFMG; Gustavo C. Teixeira, UFMG; Kessler W. J. Fonseca, UFMG; Andréa R. F. Maia, UFMG; Gabriela G. Neves, UFMG; Everton L. Romão, UFMG; Teane M. A. Silva, UFMG; Juliana P. S. Mol, UFMG; Renata M. Oliveira, Universidade Estadual do Maranhão; Márcio S. S. Araújo, Fundação Oswaldo Cruz, MG; Ernane F. Nascimento, UFMG; Olindo A. Martins-Filho, Fundação Oswaldo Cruz, MG; HUMBERTO DE MELLO BRANDAO, CNPGL; Tatiane A. Paixão, UFMG; Renato L. Santos, UFMG.pt_BR
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